List of EC numbers (EC 1)

This list contains a list of EC numbers for the first group, EC 1, oxidoreductases, placed in numerical order as determined by the Nomenclature Committee of the International Union of Biochemistry and Molecular Biology. All official information is tabulated at the website of the committee.[1] The database is developed and maintained by Andrew McDonald.[2]

EC 1.1 Acting on the CH-OH group of donors

EC 1.1.1 With Nicotinamide adenine dinucleotide or NADP as acceptor

At present (October 2021) most of the entries from 343 onwards have no Wikipedia articles
  • EC 1.1.1.343: phosphogluconate dehydrogenase (NAD+-dependent, decarboxylating)
  • EC 1.1.1.344: dTDP-6-deoxy-L-talose 4-dehydrogenase [NAD(P)+]
  • EC 1.1.1.345: D-2-hydroxyacid dehydrogenase (NAD+)
  • EC 1.1.1.346: 2,5-didehydrogluconate reductase (2-dehydro-L-gulonate-forming)
  • EC 1.1.1.347: geraniol dehydrogenase (NAD+)
  • EC 1.1.1.348: (3R)-2′-hydroxyisoflavanone reductase
  • EC 1.1.1.349: norsolorinic acid ketoreductase
  • EC 1.1.1.350: ureidoglycolate dehydrogenase (NAD+)
  • EC 1.1.1.351: phosphogluconate dehydrogenase [NAD(P)+-dependent, decarboxylating]
  • EC 1.1.1.352: 5′-hydroxyaverantin dehydrogenase
  • EC 1.1.1.353: versiconal hemiacetal acetate reductase
  • EC 1.1.1.354: farnesol dehydrogenase (NAD+)
  • EC 1.1.1.355: 2′-dehydrokanamycin reductase
  • EC 1.1.1.356: GDP-L-colitose synthase
  • EC 1.1.1.357: 3α-hydroxysteroid 3-dehydrogenase
  • EC 1.1.1.358: 2-dehydropantolactone reductase
  • EC 1.1.1.359: aldose 1-dehydrogenase [NAD(P)+]
  • EC 1.1.1.360: glucose/galactose 1-dehydrogenase
  • EC 1.1.1.361: glucose-6-phosphate 3-dehydrogenase
  • EC 1.1.1.362: aklaviketone reductase
  • EC 1.1.1.363: glucose-6-phosphate dehydrogenase [NAD(P)+]
  • EC 1.1.1.364: dTDP-4-dehydro-6-deoxy-α-D-gulose 4-ketoreductase
  • EC 1.1.1.365: D-galacturonate reductase
  • EC 1.1.1.366: L-idonate 5-dehydrogenase (NAD+)
  • EC 1.1.1.367: UDP-2-acetamido-2,6-β-L-arabino-hexul-4-ose reductase
  • EC 1.1.1.368: 6-hydroxycyclohex-1-ene-1-carbonyl-CoA dehydrogenase
  • EC 1.1.1.369: D-chiro-inositol 1-dehydrogenase
  • EC 1.1.1.370: scyllo-inositol 2-dehydrogenase (NAD+)
  • EC 1.1.1.371: scyllo-inositol 2-dehydrogenase (NADP+)
  • EC 1.1.1.372: D/L-glyceraldehyde reductase
  • EC 1.1.1.373: sulfolactaldehyde 3-reductase
  • EC 1.1.1.374: UDP-N-acetylglucosamine 3-dehydrogenase
  • EC 1.1.1.375: L-2-hydroxycarboxylate dehydrogenase [NAD(P)+]
  • EC 1.1.1.376: L-arabinose 1-dehydrogenase [NAD(P)+]
  • EC 1.1.1.377: L-rhamnose 1-dehydrogenase (NADP+)
  • EC 1.1.1.378: L-rhamnose 1-dehydrogenase [NAD(P)+]
  • EC 1.1.1.379: (R)-mandelate dehydrogenase
  • EC 1.1.1.380: L-gulonate 5-dehydrogenase
  • EC 1.1.1.381: 3-hydroxy acid dehydrogenase
  • EC 1.1.1.382: ketol-acid reductoisomerase (NAD+)
  • EC 1.1.1.383: ketol-acid reductoisomerase [NAD(P)+]
  • EC 1.1.1.384: dTDP-3,4-didehydro-2,6-dideoxy-α-D-glucose 3-reductase
  • EC 1.1.1.385: dihydroanticapsin dehydrogenase
  • EC 1.1.1.386: ipsdienol dehydrogenase
  • EC 1.1.1.387: L-serine 3-dehydrogenase (NAD+)
  • EC 1.1.1.388: glucose-6-phosphate dehydrogenase (NAD+)
  • EC 1.1.1.389: 2-dehydro-3-deoxy-L-galactonate 5-dehydrogenase
  • EC 1.1.1.390: sulfoquinovose 1-dehydrogenase
  • EC 1.1.1.391: 3β-hydroxycholanate 3-dehydrogenase (NAD+)
  • EC 1.1.1.392: 3α-hydroxycholanate dehydrogenase (NADP+)
  • EC 1.1.1.393: 3β-hydroxycholanate 3-dehydrogenase (NADP+)
  • EC 1.1.1.394: aurachin B dehydrogenase
  • EC 1.1.1.395: 3α-hydroxy bile acid-CoA-ester 3-dehydrogenase
  • EC 1.1.1.396: bacteriochlorophyllide a dehydrogenase
  • EC 1.1.1.397: β-methylindole-3-pyruvate reductase
  • EC 1.1.1.398: 2-glutathionyl-2-methylbut-3-en-1-ol dehydrogenase
  • EC 1.1.1.399: 2-oxoglutarate reductase
  • EC 1.1.1.400: 2-methyl-1,2-propanediol dehydrogenase
  • EC 1.1.1.401: 2-dehydro-3-deoxy-L-rhamnonate dehydrogenase (NAD+)
  • EC 1.1.1.402: D-erythritol 1-phosphate dehydrogenase
  • EC 1.1.1.403: D-threitol dehydrogenase (NAD+)
  • EC 1.1.1.404: tetrachlorobenzoquinone reductase
  • EC 1.1.1.405: ribitol-5-phosphate 2-dehydrogenase (NADP+)
  • EC 1.1.1.406: galactitol 2-dehydrogenase (L-tagatose-forming)
  • EC 1.1.1.407: D-altritol 5-dehydrogenase
  • EC 1.1.1.408: 4-phospho-D-threonate 3-dehydrogenase
  • EC 1.1.1.409: 4-phospho-D-erythronate 3-dehydrogenase
  • EC 1.1.1.410: D-erythronate 2-dehydrogenase
  • EC 1.1.1.411: L-threonate 2-dehydrogenase
  • EC 1.1.1.412: 2-alkyl-3-oxoalkanoate reductase
  • EC 1.1.1.413: A-factor type γ-butyrolactone 1′-reductase (1S-forming)
  • EC 1.1.1.414: L-galactonate 5-dehydrogenase
  • EC 1.1.1.415: noscapine synthase
  • EC 1.1.1.416: isopyridoxal dehydrogenase (5-pyridoxolactone-forming)
  • EC 1.1.1.417: 3β-hydroxysteroid-4β-carboxylate 3-dehydrogenase (decarboxylating)
  • EC 1.1.1.418: plant 3β-hydroxysteroid-4α-carboxylate 3-dehydrogenase (decarboxylating)
  • EC 1.1.1.419: nepetalactol dehydrogenase
  • EC 1.1.1.420: D-apiose dehydrogenase
  • EC 1.1.1.421: D-apionate oxidoisomerase
  • EC 1.1.1.422: pseudoephedrine dehydrogenase
  • EC 1.1.1.423: (1R,2S)-ephedrine 1-dehydrogenase
  • EC 1.1.1.424: D-xylose 1-dehydrogenase (NADP+, D-xylono-1,4-lactone-forming)
  • EC 1.1.1.425: levoglucosan dehydrogenase
  • EC 1.1.1.426: UDP-N-acetyl-α-D-quinovosamine dehydrogenase

EC 1.1.2 With a cytochrome as acceptor

*No Wikipedia article

EC 1.1.3 With oxygen as acceptor

*No Wikipedia article

EC 1.1.4 With a disulfide as acceptor

  • EC 1.1.4.1: Now EC 1.17.4.4, vitamin-K-epoxide reductase (warfarin-sensitive)
  • EC 1.1.4.2: Now EC 1.17.4.5, vitamin-K-epoxide reductase (warfarin-insensitive)

EC 1.1.5 With a quinone or similar compound as acceptor

EC 1.1.9 With a copper protein as acceptor

EC 1.1.98 With other, known, acceptors

*No Wikipedia article

EC 1.1.99 With unknown physiological acceptors

*No Wikipedia article

EC 1.2 Acting on the aldehyde or oxo group of donors

EC 1.2.1 With NAD+ or NADP+ as acceptor

* No Wikipedia article

EC 1.2.2 With a cytochrome as acceptor

  • EC 1.2.2.1: formate dehydrogenase (cytochrome)
  • EC 1.2.2.2: Now covered by EC 1.2.5.1, pyruvate dehydrogenase (quinone)
  • EC 1.2.2.3: Now EC 1.17.2.3, formate dehydrogenase (cytochrome-c-553)
  • EC 1.2.2.4: Now classified as EC 1.2.5.3, aerobic carbon monoxide dehydrogenase

EC 1.2.3 With oxygen as acceptor

* No Wikipedia article

EC 1.2.4 With a disulfide as acceptor

EC 1.2.5 With a quinone or similar compound as acceptor

*No Wikipedia article

EC 1.2.7 With an iron–sulfur protein as acceptor

*No Wikipedia article

EC 1.2.99: With unknown physiological acceptors

  • EC 1.2.99.1: Now EC 1.17.99.4, uracil/thymine dehydrogenase
  • EC 1.2.99.2: Now EC 1.2.7.4, carbon-monoxide dehydrogenase (ferredoxin)
  • EC 1.2.99.3: Now EC 1.2.5.2, aldehyde dehydrogenase (quinone)
  • EC 1.2.99.4: Now EC 1.2.98.1, formaldehyde dismutase
  • EC 1.2.99.5: Now EC 1.2.7.12, formylmethanofuran dehydrogenase
  • EC 1.2.99.6: carboxylate reductase
  • EC 1.2.99.7: aldehyde dehydrogenase (FAD-independent)
  • EC 1.2.99.8: glyceraldehyde dehydrogenase (FAD-containing) *
  • EC 1.2.99.9: Now EC 1.17.98.3, formate dehydrogenase (coenzyme F420)
  • EC 1.2.99.10: 4,4′-diapolycopenoate synthase *
*No Wikipedia article

EC 1.3 Acting on the CH-CH group of donors

EC 1.3.1 With NAD+ or NADP+ as acceptor

*No Wikipedia article

EC 1.3.2 With a cytochrome as acceptor

EC 1.3.3 With oxygen as acceptor

EC 1.3.5 With a quinone or related compound as acceptor

EC 1.3.7 With an iron–sulfur protein as acceptor

EC 1.3.8 With a flavin as acceptor

*No Wikipedia article

EC 1.3.98 With FMN acceptor

  • EC 1.3.98.1: dihydroorotate dehydrogenase (fumarate)
  • EC 1.3.98.2: Now EC 1.3.4.1, fumarate reductase (CoM/CoB)
  • EC 1.3.98.3: coproporphyrinogen dehydrogenase *
  • EC 1.3.98.4: 5a,11a-dehydrotetracycline reductase *
  • EC 1.3.98.5: hydrogen peroxide-dependent heme synthase *
  • EC 1.3.98.6: AdoMet-dependent heme synthase *
  • EC 1.3.98.7: [mycofactocin precursor peptide]-tyrosine decarboxylase
*No Wikipedia article

EC 1.3.99 With unknown physiological acceptors

*No Wikipedia article

EC 1.4 Acting on the CH-NH2 group of donors

EC 1.4.1 With NAD+ or NADP+ as acceptor

*No Wikipedia article

EC 1.4.2 With a cytochrome as acceptor

EC 1.4.3 With oxygen as acceptor

*No Wikipedia article

EC 1.4.4 With a disulfide as acceptor

EC 1.4.5 With a quinone or other compound as acceptor

EC 1.4.7 With an iron–sulfur protein as acceptor

EC 1.4.9 With a copper protein as acceptor

EC 1.4.98 With tryptophan tryptophylquinone acceptors

EC 1.4.99 With unknown physiological acceptors

*No Wikipedia article

EC 1.5 Acting on the CH-NH group of donors

EC 1.5.1 With NAD+ or NADP+ as acceptor

*No Wikipedia article

EC 1.5.3 With oxygen as acceptor

*No Wikipedia article

EC 1.5.4 With a disulfide as acceptor

EC 1.5.5 With a quinone or similar compound as acceptor

*No Wikipedia article

EC 1.5.7 With an iron–sulfur protein as acceptor

*No Wikipedia article

EC 1.5.8 With a flavin or flavoprotein as acceptor

EC 1.5.98 With other, known, physiological acceptors

  • EC 1.5.98.1: ethylenetetrahydromethanopterin dehydrogenase
  • EC 1.5.98.2: 5,10-methylenetetrahydromethanopterin reductase
  • EC 1.5.98.3: coenzyme F420:methanophenazine dehydrogenase

EC 1.5.99 With unknown physiological acceptors

*No Wikipedia article

EC 1.6 Acting on NADH or NADPH

EC 1.6.1 With NAD or NADP as acceptor

EC 1.6.2 With a heme protein as acceptor

EC 1.6.3 With oxygen as acceptor

  • EC 1.6.3.1: NAD(P)H oxidase (H2O2-forming)
  • EC 1.6.3.2: NAD(P)H oxidase (H2O-forming) *
  • EC 1.6.3.3: NADH oxidase (H2O2-forming) *
  • EC 1.6.3.4: NADH oxidase (H2O-forming) *
  • EC 1.6.3.5: renalase *
*No Wikipedia article

EC 1.6.4 With a disulfide as acceptor (deleted sub-class)

  • EC 1.6.4.1: now EC 1.8.1.6 cystine reductase
  • EC 1.6.4.2: now EC 1.8.1.7 glutathione-disulfide reductase
  • EC 1.6.4.3: now EC 1.8.1.4 dihydrolipoyl dehydrogenase
  • EC 1.6.4.4: now EC 1.8.1.8 protein-disulfide reductase
  • EC 1.6.4.5: now EC 1.8.1.9 thioredoxin-disulfide reductase
  • EC 1.6.4.6: now EC 1.8.1.10 CoA-glutathione reductase
  • EC 1.6.4.7: now EC 1.8.1.11 asparagusate reductase
  • EC 1.6.4.8: now EC 1.8.1.12 trypanothione-disulfide reductase
  • EC 1.6.4.9: now EC 1.8.1.13 bis-γ-glutamylcystine reductase
  • EC 1.6.4.10: now EC 1.8.1.14 CoA-disulfide reductase

EC 1.6.5 With a quinone or similar compound as acceptor

*No Wikipedia article

EC 1.6.6 With a nitrogenous group as acceptor

  • EC 1.6.6.1: Now EC 1.7.1.1, nitrate reductase (NADH)
  • EC 1.6.6.2: Now EC 1.7.1.2, nitrate reductase [NAD(P)H]
  • EC 1.6.6.3: Now EC 1.7.1.3, nitrate reductase (NADPH)
  • EC 1.6.6.4: Now EC 1.7.1.4, nitrite reductase [NAD(P)H]
  • EC 1.6.6.5: Now EC 1.7.2.1, nitrite reductase (NO-forming)
  • EC 1.6.6.6: Now EC 1.7.1.5, hyponitrite reductase
  • EC 1.6.6.7: Now EC 1.7.1.6, azobenzene reductase
  • EC 1.6.6.8: Now EC 1.7.1.7, GMP reductase
  • EC 1.6.6.9: Now known to be catalysed by EC 1.7.2.3, trimethylamine-N-oxide reductase
  • EC 1.6.6.10: Now EC 1.7.1.9, nitroquinoline-N-oxide reductase]
  • EC 1.6.6.11: Now EC 1.7.1.10, hydroxylamine reductase (NADH)
  • EC 1.6.6.12: Now EC 1.7.1.11, 4-(dimethylamino)phenylazoxybenzene reductase
  • EC 1.6.6.13: Now EC 1.7.1.12, N-hydroxy-2-acetamidofluorene reductase

EC 1.6.7 With an iron–sulfur protein as acceptor (deleted sub-subclass)

  • EC 1.6.7.1: now EC 1.18.1.2 ferredoxin—NADP+ reductase
  • EC 1.6.7.2: now EC 1.18.1.1 rubredoxin—NAD+ reductase
  • EC 1.6.7.3: now EC 1.18.1.3 ferredoxin—NAD+ reductase

EC 1.6.8 With a flavin as acceptor (deleted sub-subclass)

  • EC 1.6.8.1: Now EC 1.5.1.29 FMN reductase
  • EC 1.6.8.2: Now EC 1.5.1.30 flavin reductase

EC 1.6.99 With unknown physiological acceptors

  • EC 1.6.99.1: NADPH dehydrogenase
  • EC 1.6.99.2: Now EC 1.6.5.2, NAD(P)H dehydrogenase (quinone
  • EC 1.6.99.3: The activity is covered by EC 7.1.1.2, NADH:ubiquinone reductase (H+-translocating)
  • EC 1.6.99.4: Now EC 1.18.1.2, ferredoxin—NADP+ reductase
  • EC 1.6.99.5: Now EC 1.6.5.11, NADH dehydrogenase (quinone)
  • EC 1.6.99.6: Now EC 1.6.5.10, NADPH dehydrogenase (quinone)
  • EC 1.6.99.7: Now EC 1.5.1.34, 6,7-dihydropteridine reductase
  • EC 1.6.99.8: Deleted
  • EC 1.6.99.9: Now EC 1.16.1.4, cob(II)alamin reductase
  • EC 1.6.99.10: included in EC 1.5.1.34, 6,7-dihydropteridine reductase
  • EC 1.6.99.11: Deleted
  • EC 1.6.99.12: Now EC 1.16.1.6, cyanocobalamin reductase (cyanide-eliminating)
  • EC 1.6.99.13: Now EC 1.16.1.7, ferric-chelate reductase

EC 1.7 Acting on other nitrogenous compounds as donors

EC 1.7.1 With NAD+ or NADP+ as acceptor

EC 1.7.2 With a cytochrome as acceptor

*No Wikipedia article

EC 1.7.3 With oxygen as acceptor

*No Wikipedia article

EC 1.7.5 With a quinone or similar compound as acceptor

EC 1.7.6 With a nitrogenous group as acceptor

EC 1.7.7 With an iron–sulfur protein as acceptor

EC 1.7.99 With other acceptors

  • EC 1.7.99.1: hydroxylamine reductase
  • EC 1.7.99.2: deleted: reaction may have been due to the combined action of EC 1.7.99.6 nitrous-oxide reductase and EC 1.7.99.7 nitric-oxide reductase
  • EC 1.7.99.3: Now included with EC 1.7.2.1, nitrite reductase (NO-forming)
  • EC 1.7.99.4: Now EC 1.7.1.1, nitrate reductase (NADH), EC 1.7.1.2, nitrate reductase [NAD(P)H], EC 1.7.1.3, nitrate reductase (NADPH), EC 1.7.5.1, nitrate reductase (quinone), EC 1.7.7.2, nitrate reductase (ferredoxin) and EC 1.9.6.1, nitrate reductase (cytochrome)
  • EC 1.7.99.5: Now included with EC 1.5.1.20, methylenetetrahydrofolate reductase [NAD(P)H]
  • EC 1.7.99.6: Now EC 1.7.2.4 nitrous-oxide reductase
  • EC 1.7.99.7: Now EC 1.7.2.5 nitric oxide reductase (cytochrome c)
  • EC 1.7.99.8: hydroxylamine oxidoreductase
  • EC 1.7.99.8: Now classified as EC 1.7.2.8, hydrazine dehydrogenase

EC 1.8 Acting on a sulfur group of donors

EC 1.8.1 With NAD+ or NADP+ as acceptor

*No Wikipedia article

EC 1.8.2 With a cytochrome as acceptor

*No Wikipedia article

EC 1.8.3 With oxygen as acceptor

*No Wikipedia article

EC 1.8.4 With a disulfide as acceptor

*No Wikipedia article

EC 1.8.5 With a quinone or similar compound as acceptor

*No Wikipedia article

EC 1.8.6 With a nitrogenous group as acceptor (deleted sub-subclass)

  • EC 1.8.6.1: Now included with EC 2.5.1.18 glutathione transferase

EC 1.8.7 With an iron–sulfur protein as acceptor

*No Wikipedia article

EC 1.8.98 With other, known, acceptors

EC 1.8.99 With other acceptors

  • EC 1.8.99.1: Now covered by EC 1.8.1.2, assimilatory sulfite reductase (NADPH) and EC 1.8.7.1, assimilatory sulfite reductase (ferredoxin)
  • EC 1.8.99.2: adenylyl-sulfate reductase
  • EC 1.8.99.3: an in vitro artifact of EC 1.8.99.5, dissimilatory sulfite reductase
  • EC 1.8.99.4: Now EC 1.8.4.8, phosphoadenylyl-sulfate reductase (thioredoxin)
  • EC 1.8.99.5: dissimilatory sulfite reductase *
*No Wikipedia article

EC 1.9 Acting on a heme group of donors

EC 1.9.3 With oxygen as acceptor

  • EC 1.9.3.1: Now EC 7.1.1.9, cytochrome-c oxidase
  • EC 1.9.3.2: Now included with EC 1.7.2.1, nitrite reductase (NO-forming)

EC 1.9.6 With a nitrogenous group as acceptor

EC 1.9.98 With other, known, physiological acceptors

  • EC 1.9.98.1: iron—cytochrome-c reductase

EC 1.9.99 With other acceptors

  • EC 1.9.99.1: Now EC 1.9.98.1, iron—cytochrome-c reductase

EC 1.10 Acting on diphenols and related substances as donors

EC 1.10.1 With NAD+ or NADP+ as acceptor

EC 1.10.2 With a cytochrome as acceptor

  • EC 1.10.2.1: The activity is covered by EC 7.2.1.3, ascorbate ferrireductase (transmembrane)
  • EC 1.10.2.2: Now EC 7.1.1.8, quinol—cytochrome-c reductase

EC 1.10.3 With oxygen as acceptor

  • EC 1.10.3.1: catechol oxidase
  • EC 1.10.3.2: laccase
  • EC 1.10.3.3: L-ascorbate oxidase
  • EC 1.10.3.4: o-aminophenol oxidase
  • EC 1.10.3.5: 3-hydroxyanthranilate oxidase
  • EC 1.10.3.6: rifamycin-B oxidase
  • EC 1.10.3.7: Now EC 1.21.3.4, sulochrin oxidase [(+)-bisdechlorogeodin-forming]
  • EC 1.10.3.8: Now EC 1.21.3.5, sulochrin oxidase [(-)-bisdechlorogeodin-forming]
  • EC 1.10.3.9: photosystem II
  • EC 1.10.3.10: Now EC 7.1.1.3, ubiquinol oxidase (H+-transporting)
  • EC 1.10.3.11: ubiquinol oxidase (non-electrogenic)
  • EC 1.10.3.12: Now EC 7.1.1.5, menaquinol oxidase (H +-transporting)
  • EC 1.10.3.13: Now EC 7.1.1.4, caldariellaquinol oxidase (H+-transporting)
  • EC 1.10.3.14: Now EC 7.1.1.7, ubiquinol oxidase (electrogenic, proton-motive force generating)
  • EC 1.10.3.15: grixazone synthase *
  • EC 1.10.3.16: dihydrophenazinedicarboxylate synthase *
  • EC 1.10.3.17: superoxide oxidase *
*No Wikipedia article

EC 1.10.5 With a quinone or related compound as acceptor

  • EC 1.10.5.1: ribosyldihydronicotinamide dehydrogenase (quinone)
*No Wikipedia article

EC 1.10.9 With a copper protein as acceptor

  • EC 1.10.9.1: Now EC 7.1.1.6, plastoquinol—plastocyanin reductase

EC 1.10.99 With unknown physiological acceptors

  • EC 1.10.99.1: Now EC 1.10.9.1 plastoquinol—plastocyanin reductase
  • EC 1.10.99.2: Now EC 1.10.5.1 ribosyldihydronicotinamide dehydrogenase (quinone)
  • EC 1.10.99.3: Now EC 1.23.5.1 violaxanthin de-epoxidase

EC 1.11 Acting on a peroxide as acceptor

EC 1.11.1 Peroxidases

*No Wikipedia article

EC 1.11.2 Peroxygenase

*No Wikipedia article

EC 1.12 Acting on hydrogen as donor

EC 1.12.1 With NAD+ or NADP+ as acceptor

*No Wikipedia article

EC 1.12.2 With a cytochrome as acceptor

EC 1.12.5 With a quinone or similar compound as acceptor

EC 1.12.7 With an iron–sulfur protein as acceptor

EC 1.12.98 With other known acceptors

EC 1.12.99 With unknown physiological acceptors

  • EC 1.12.99.1: Now EC 1.12.98.1, coenzyme F420 hydrogenase
  • EC 1.12.99.2: Now shown to be two enzymes, EC 1.12.98.3, Methanosarcina-phenazine hydrogenase and EC 1.8.98.1, CoB—CoM heterodisulfide reductase
  • EC 1.12.99.3: Now EC 1.12.5.1, hydrogen:quinone oxidoreductase
  • EC 1.12.99.4: Now EC 1.12.98.2, 5,10-methenyltetrahydromethanopterin hydrogenase
  • EC 1.12.99.5: Identical to EC 1.13.11.47, 3-hydroxy-4-oxoquinoline 2,4-dioxygenase
  • EC 1.12.99.6: hydrogenase (acceptor)

EC 1.13 Acting on single donors with incorporation of molecular oxygen (oxygenases)

EC 1.13.11 With incorporation of two atoms of oxygen

*No Wikipedia article

EC 1.13.12 With incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases)

*No Wikipedia article

EC 1.13.99 Miscellaneous

EC 1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

EC 1.14.1 With NADH or NADPH as one donor (deleted sub-subclass)

  • EC 1.14.1.1: now EC 1.14.14.1, unspecific monooxygenase
  • EC 1.14.1.2: now EC 1.14.13.9, kynurenine 3-monooxygenase
  • EC 1.14.1.3: deleted, covered by EC 1.14.99.7, squalene monooxygenase and EC 5.4.99.7, lanosterol synthase
  • EC 1.14.1.4: now EC 1.14.99.2, kynurenine 7,8-hydroxylase
  • EC 1.14.1.5: now EC 1.14.13.5; imidazoleacetate 4-monooxygenase
  • EC 1.14.1.6: now EC 1.14.15.4, steroid 11β-monooxygenase
  • EC 1.14.1.7: now EC 1.14.99.9, steroid 17α-monooxygenase
  • EC 1.14.1.8: now EC 1.14.99.10, steroid 21-monooxygenase
  • EC 1.14.1.9: deleted
  • EC 1.14.1.10: now EC 1.14.99.11 estradiol 6β-monooxygenase
  • EC 1.14.1.11: deleted

EC 1.14.2 With ascorbate as one donor (deleted sub-subclass)

  • EC 1.14.2.1: now EC 1.14.17.1, dopamine β-monooxygenase
  • EC 1.14.2.2: now EC 1.13.11.27, 4-hydroxyphenylpyruvate dioxygenase

EC 1.14.3 With reduced pteridine as one donor (deleted sub-subclass)

  • EC 1.14.3.1: now EC 1.14.16.1, phenylalanine 4-monooxygenase

EC 1.14.11 With 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors

EC 1.14.12 With NADH or NADPH as one donor, and incorporation of two atoms of oxygen into one donor

*No Wikipedia article

EC 1.14.13 With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor

Most of the entries from here on have no Wikipedia articles
  • EC 1.14.13.167: 4-nitrophenol 4-monooxygenase
  • EC 1.14.13.168: indole-3-pyruvate monooxygenase
  • EC 1.14.13.169: Now EC 1.14.18.5, sphingolipid C4-monooxygenase
  • EC 1.14.13.170: pentalenolactone D synthase
  • EC 1.14.13.171: neopentalenolactone D synthase
  • EC 1.14.13.172: salicylate 5-hydroxylase
  • EC 1.14.13.173: Now EC 1.14.14.115, 11-oxo-β-amyrin 30-oxidase
  • EC 1.14.13.174: Now EC 1.14.14.116, averantin hydroxylase
  • EC 1.14.13.175: Now EC 1.14.14.117, aflatoxin B synthase
  • EC 1.14.13.176: Now EC 1.14.14.118, tryprostatin B 6-hydroxylase
  • EC 1.14.13.177: Now EC 1.14.14.119, fumitremorgin C monooxygenase
  • EC 1.14.13.178: methylxanthine N 1-demethylase
  • EC 1.14.13.179: methylxanthine N 3-demethylase
  • EC 1.14.13.180: aklavinone 12-hydroxylase
  • EC 1.14.13.181: 13-deoxydaunorubicin hydroxylase
  • EC 1.14.13.182: 2-heptyl-3-hydroxy-4(1H)-quinolone synthase
  • EC 1.14.13.183: Now EC 1.14.14.120, dammarenediol 12-hydroxylase
  • EC 1.14.13.184: Now EC 1.14.14.121, protopanaxadiol 6-hydroxylase
  • EC 1.14.13.185: Now EC 1.14.15.33, pikromycin synthase
  • EC 1.14.13.186: Now EC 1.14.15.34, 20-oxo-5-O-mycaminosyltylactone 23-monooxygenase
  • EC 1.14.13.187: L-evernosamine nitrososynthase
  • EC 1.14.13.188: Now EC 1.14.15.35, 6-deoxyerythronolide B hydroxylase
  • EC 1.14.13.189: 5-methyl-1-naphthoate 3-hydroxylase
  • EC 1.14.13.190: Now EC 1.14.14.175, ferruginol synthase
  • EC 1.14.13.191: Now EC 1.14.14.70, ent-sandaracopimaradiene 3-hydroxylase
  • EC 1.14.13.192: Now EC 1.14.14.122, oryzalexin E synthase
  • EC 1.14.13.193: Now EC 1.14.14.123, oryzalexin D synthase
  • EC 1.14.13.194: Now EC 1.14.14.78, phylloquinone ω-hydroxylase
  • EC 1.14.13.195: L-ornithine N 5-monooxygenase (NADPH)
  • EC 1.14.13.196: L-ornithine N 5-monooxygenase [NAD(P)H]
  • EC 1.14.13.197: Now EC 1.14.14.124, dihydromonacolin L hydroxylase
  • EC 1.14.13.198: Now EC 1.14.14.125, monacolin L hydroxylase
  • EC 1.14.13.199: Now EC 1.14.14.79, docosahexaenoic acid ω-hydroxylase
  • EC 1.14.13.200: tetracenomycin A2 monooxygenase-dioxygenase
  • EC 1.14.13.201: Now EC 1.14.14.126, β-amyrin 28-monooxygenase
  • EC 1.14.13.202: Now EC 1.14.14.127, methyl farnesoate epoxidase
  • EC 1.14.13.203: Now EC 1.14.14.128, farnesoate epoxidase
  • EC 1.14.13.204: Now EC 1.14.14.129, long-chain acyl-CoA ω-monooxygenase
  • EC 1.14.13.205: Now EC 1.14.14.80, long-chain fatty acid ω-monooxygenase
  • EC 1.14.13.206: Now EC 1.14.14.130, laurate 7-monooxygenase
  • EC 1.14.13.207: Now EC 1.14.14.31, ipsdienol synthase
  • EC 1.14.13.208: benzoyl-CoA 2,3-epoxidase
  • EC 1.14.13.209: salicyloyl-CoA 5-hydroxylase
  • EC 1.14.13.210: 4-methyl-5-nitrocatechol 5-monooxygenase
  • EC 1.14.13.211: rifampicin monooxygenase
  • EC 1.14.13.212: 1,3,7-trimethyluric acid 5-monooxygenase
  • EC 1.14.13.213: Now EC 1.14.14.131, bursehernin 5-monooxygenase
  • EC 1.14.13.214: Now EC 1.14.14.132, (–)-4′-demethyl-deoxypodophyllotoxin 4-hydroxylase
  • EC 1.14.13.215: protoasukamycin 4-monooxygenase
  • EC 1.14.13.216: asperlicin C monooxygenase
  • EC 1.14.13.217: protodeoxyviolaceinate monooxygenase
  • EC 1.14.13.218: 5-methylphenazine-1-carboxylate 1-monooxygenase
  • EC 1.14.13.219: resorcinol 4-hydroxylase (NADPH)
  • EC 1.14.13.220: resorcinol 4-hydroxylase (NADH)
  • EC 1.14.13.221: Now EC 1.14.15.28, cholest-4-en-3-one 26-monooxygenase [(25R)-3-oxocholest-4-en-26-oate forming]
  • EC 1.14.13.222: aurachin C monooxygenase/isomerase
  • EC 1.14.13.223: 3-hydroxy-4-methylanthranilyl-[aryl-carrier protein] 5-monooxygenase
  • EC 1.14.13.224: violacein synthase
  • EC 1.14.13.225: F-actin monooxygenase
  • EC 1.14.13.226: acetone monooxygenase (methyl acetate-forming)
  • EC 1.14.13.227: propane 2-monooxygenase
  • EC 1.14.13.228: jasmonic acid 12-hydroxylase
  • EC 1.14.13.229: tert-butyl alcohol monooxygenase
  • EC 1.14.13.230: butane monooxygenase (soluble)
  • EC 1.14.13.231: tetracycline 11a-monooxygenase
  • EC 1.14.13.232: 6-methylpretetramide 4-monooxygenase
  • EC 1.14.13.233: 4-hydroxy-6-methylpretetramide 12a-monooxygenase
  • EC 1.14.13.234: 5a,11a-dehydrotetracycline 5-monooxygenase
  • EC 1.14.13.235: indole-3-acetate monooxygenase
  • EC 1.14.13.236: toluene 4-monooxygenase
  • EC 1.14.13.237: aliphatic glucosinolate S-oxygenase
  • EC 1.14.13.238: dimethylamine monooxygenase
  • EC 1.14.13.239: carnitine monooxygenase
  • EC 1.14.13.240: 2-polyprenylphenol 6-hydroxylase
  • EC 1.14.13.241: 5-pyridoxate monooxygenase
  • EC 1.14.13.242: 3-hydroxy-2-methylpyridine-5-carboxylate monooxygenase
  • EC 1.14.13.243: toluene 2-monooxygenase
  • EC 1.14.13.244: phenol 2-monooxygenase (NADH)
  • EC 1.14.13.245: assimilatory dimethylsulfide S-monooxygenase
  • EC 1.14.13.246: 4β-methylsterol monooxygenase
  • EC 1.14.13.247: stachydrine N-demethylase

EC 1.14.14 With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen

Most of the entries from here on have no Wikipedia articles
  • EC 1.14.14.14: aromatase
  • EC 1.14.14.15: (3S)-3-amino-3-(3-chloro-4-hydroxyphenyl)propanoyl-[peptidyl-carrier protein SgcC2] monooxygenase
  • EC 1.14.14.16: steroid 21-monooxygenase
  • EC 1.14.14.17: squalene monooxygenase
  • EC 1.14.14.18: heme oxygenase (biliverdin-producing)
  • EC 1.14.14.19: steroid 17α-monooxygenase
  • EC 1.14.14.20: phenol 2-monooxygenase (FADH2)
  • EC 1.14.14.21: dibenzothiophene monooxygenase
  • EC 1.14.14.22: dibenzothiophene sulfone monooxygenase
  • EC 1.14.14.23: cholesterol 7α-monooxygenase
  • EC 1.14.14.24: vitamin D 25-hydroxylase
  • EC 1.14.14.25: cholesterol 24-hydroxylase
  • EC 1.14.14.26: 24-hydroxycholesterol 7α-hydroxylase
  • EC 1.14.14.27: resorcinol 4-hydroxylase (FADH2)
  • EC 1.14.14.28: long-chain alkane monooxygenase
  • EC 1.14.14.29: 25/26-hydroxycholesterol 7α-hydroxylase
  • EC 1.14.14.30: isobutylamine N-monooxygenase
  • EC 1.14.14.31: ipsdienol synthase
  • EC 1.14.14.32: 17α-hydroxyprogesterone deacetylase
  • EC 1.14.14.33: ethylenediaminetetraacetate monooxygenase
  • EC 1.14.14.34: methanesulfonate monooxygenase (FMNH2)
  • EC 1.14.14.35: dimethylsulfone monooxygenase
  • EC 1.14.14.36: tyrosine N-monooxygenase
  • EC 1.14.14.37: 4-hydroxyphenylacetaldehyde oxime monooxygenase
  • EC 1.14.14.38: valine N-monooxygenase
  • EC 1.14.14.39: isoleucine N-monooxygenase
  • EC 1.14.14.40: phenylalanine N-monooxygenase
  • EC 1.14.14.41: (E)-2-methylbutanal oxime monooxygenase
  • EC 1.14.14.42: homomethionine N-monooxygenase
  • EC 1.14.14.43: (methylsulfanyl)alkanaldoxime N-monooxygenase
  • EC 1.14.14.44: phenylacetaldehyde oxime monooxygenase
  • EC 1.14.14.45: aromatic aldoxime N-monooxygenase
  • EC 1.14.14.46: pimeloyl-[acyl-carrier protein] synthase
  • EC 1.14.14.47: nitric-oxide synthase (flavodoxin)
  • EC 1.14.14.48: jasmonoyl-L-amino acid 12-hydroxylase
  • EC 1.14.14.49: 12-hydroxyjasmonoyl-L-amino acid 12-hydroxylase
  • EC 1.14.14.50: tabersonine 3-oxygenase
  • EC 1.14.14.51: (S)-limonene 6-monooxygenase
  • EC 1.14.14.52: (S)-limonene 7-monooxygenase
  • EC 1.14.14.53: (R)-limonene 6-monooxygenase
  • EC 1.14.14.54: phenylacetate 2-hydroxylase
  • EC 1.14.14.55: quinine 3-monooxygenase
  • EC 1.14.14.56: 1,8-cineole 2-exo-monooxygenase
  • EC 1.14.14.57: taurochenodeoxycholate 6α-hydroxylase
  • EC 1.14.14.58: trimethyltridecatetraene synthase
  • EC 1.14.14.59: dimethylnonatriene synthase
  • EC 1.14.14.60: ferruginol monooxygenase
  • EC 1.14.14.61: carnosic acid synthase
  • EC 1.14.14.62: salviol synthase
  • EC 1.14.14.63: β-amyrin 16β-monooxygenase
  • EC 1.14.14.64: β-amyrin 6β-monooxygenase
  • EC 1.14.14.65: sugiol synthase
  • EC 1.14.14.66: marmesin synthase
  • EC 1.14.14.67: 11-hydroxysugiol 20-monooxygenase
  • EC 1.14.14.68: syn-pimaradiene 3-monooxygenase
  • EC 1.14.14.69: ent-cassadiene hydroxylase
  • EC 1.14.14.70: ent-sandaracopimaradiene 3-hydroxylase
  • EC 1.14.14.71: cucurbitadienol 11-hydroxylase
  • EC 1.14.14.72: drimenol monooxygenase
  • EC 1.14.14.73: albendazole monooxygenase (sulfoxide-forming)
  • EC 1.14.14.74: albendazole monooxygenase (hydroxylating)
  • EC 1.14.14.75: fenbendazole monooxygenase (4′-hydroxylating)
  • EC 1.14.14.76: ent-isokaurene C2/C3-hydroxylase
  • EC 1.14.14.77: phenylacetonitrile α-monooxygenase
  • EC 1.14.14.78: phylloquinone ω-hydroxylase
  • EC 1.14.14.79: docosahexaenoic acid ω-hydroxylase
  • EC 1.14.14.80: long-chain fatty acid ω-monooxygenase
  • EC 1.14.14.81: flavanoid 3′,5′-hydroxylase
  • EC 1.14.14.82: flavonoid 3′-monooxygenase
  • EC 1.14.14.83: geraniol 8-hydroxylase
  • EC 1.14.14.84: linalool 8-monooxygenase
  • EC 1.14.14.85: 7-deoxyloganate 7-hydroxylase
  • EC 1.14.14.86: ent-kaurene monooxygenase
  • EC 1.14.14.87: 2-hydroxyisoflavanone synthase
  • EC 1.14.14.88: isoflavone 3′-hydroxylase
  • EC 1.14.14.89: 4′-methoxyisoflavone 2′-hydroxylase
  • EC 1.14.14.90: isoflavone 2′-hydroxylase
  • EC 1.14.14.91: trans-cinnamate 4-monooxygenase
  • EC 1.14.14.92: benzoate 4-monooxygenase
  • EC 1.14.14.93: 3,9-dihydroxypterocarpan 6a-monooxygenase
  • EC 1.14.14.94: leukotriene-B4 20-monooxygenase
  • EC 1.14.14.95: germacrene A hydroxylase
  • EC 1.14.14.96: 5-O-(4-coumaroyl)-D-quinate 3′-monooxygenase
  • EC 1.14.14.97: methyltetrahydroprotoberberine 14-monooxygenase
  • EC 1.14.14.98: protopine 6-monooxygenase
  • EC 1.14.14.99: (S)-limonene 3-monooxygenase
  • EC 1.14.14.100: dihydrosanguinarine 10-monooxygenase
  • EC 1.14.14.101: dihydrochelirubine 12-monooxygenase
  • EC 1.14.14.102: N-methylcoclaurine 3′-monooxygenase
  • EC 1.14.14.103: tabersonine 16-hydroxylase
  • EC 1.14.14.104: vinorine hydroxylase
  • EC 1.14.14.105: taxane 10β-hydroxylase
  • EC 1.14.14.106: taxane 13α-hydroxylase
  • EC 1.14.14.107: ent-kaurenoic acid monooxygenase
  • EC 1.14.14.108: 2,5-diketocamphane 1,2-monooxygenase
  • EC 1.14.14.109: 3-hydroxyindolin-2-one monooxygenase
  • EC 1.14.14.110: 2-hydroxy-1,4-benzoxazin-3-one monooxygenase
  • EC 1.14.14.111: 9β-pimara-7,15-diene oxidase
  • EC 1.14.14.112: ent-cassa-12,15-diene 11-hydroxylase
  • EC 1.14.14.113: α-humulene 10-hydroxylase
  • EC 1.14.14.114: amorpha-4,11-diene 12-monooxygenase
  • EC 1.14.14.115: 11-oxo-β-amyrin 30-oxidase
  • EC 1.14.14.116: averantin hydroxylase
  • EC 1.14.14.117: aflatoxin B synthase
  • EC 1.14.14.118: tryprostatin B 6-hydroxylase
  • EC 1.14.14.119: fumitremorgin C monooxygenase
  • EC 1.14.14.120: dammarenediol 12-hydroxylase
  • EC 1.14.14.121: protopanaxadiol 6-hydroxylase
  • EC 1.14.14.122: oryzalexin E synthase
  • EC 1.14.14.123: oryzalexin D synthase
  • EC 1.14.14.124: dihydromonacolin L hydroxylase
  • EC 1.14.14.125: monacolin L hydroxylase
  • EC 1.14.14.126: β-amyrin 28-monooxygenase
  • EC 1.14.14.127: methyl farnesoate epoxidase
  • EC 1.14.14.128: farnesoate epoxidase
  • EC 1.14.14.129: long-chain acyl-CoA ω-monooxygenase
  • EC 1.14.14.130: laurate 7-monooxygenase
  • EC 1.14.14.131: bursehernin 5′-monooxygenase
  • EC 1.14.14.132: (–)-4′-demethyl-deoxypodophyllotoxin 4-hydroxylase
  • EC 1.14.14.133: 1,8-cineole 2-endo-monooxygenase
  • EC 1.14.14.134: β-amyrin 24-hydroxylase
  • EC 1.14.14.135: glyceollin synthase
  • EC 1.14.14.136: deoxysarpagine hydroxylase
  • EC 1.14.14.137: (+)-abscisic acid 8′-hydroxylase
  • EC 1.14.14.138: lithocholate 6β-hydroxylase
  • EC 1.14.14.139: 5β-cholestane-3α,7α-diol 12α-hydroxylase
  • EC 1.14.14.140: Now included with EC 1.14.14.162 EC 1.14.14.162, flavanone 2-hydroxylase
  • EC 1.14.14.141: psoralen synthase
  • EC 1.14.14.142: 8-dimethylallylnaringenin 2′-hydroxylase
  • EC 1.14.14.143: (+)-menthofuran synthase
  • EC 1.14.14.144: abieta-7,13-diene hydroxylase
  • EC 1.14.14.145: abieta-7,13-dien-18-ol hydroxylase
  • EC 1.14.14.146: geranylgeraniol 18-hydroxylase
  • EC 1.14.14.147: 3-epi-6-deoxocathasterone 23-monooxygenase
  • EC 1.14.14.148: angelicin synthase
  • EC 1.14.14.149: 5-epiaristolochene 1,3-dihydroxylase
  • EC 1.14.14.150: costunolide synthase
  • EC 1.14.14.151: premnaspirodiene oxygenase
  • EC 1.14.14.152: β-amyrin 11-oxidase
  • EC 1.14.14.153: indole-2-monooxygenase
  • EC 1.14.14.154: sterol 14α-demethylase
  • EC 1.14.14.155: 3,6-diketocamphane 1,2-monooxygenase
  • EC 1.14.14.156: tryptophan N-monooxygenase
  • EC 1.14.14.157: indolin-2-one monooxygenase
  • EC 1.14.14.158: carotenoid ε hydroxylase
  • EC 1.14.14.159: dolabradiene monooxygenase
  • EC 1.14.14.160: zealexin A1 synthase
  • EC 1.14.14.161: nepetalactol monooxygenase
  • EC 1.14.14.162: flavanone 2-hydroxylase
  • EC 1.14.14.163: (S)-1-hydroxy-N-methylcanadine 13-hydroxylase
  • EC 1.14.14.164: fraxetin 5-hydroxylase
  • EC 1.14.14.165: indole-3-carbonyl nitrile 4-hydroxylase
  • EC 1.14.14.166: (S)-N-methylcanadine 1-hydroxylase
  • EC 1.14.14.167: (13S,14R)-13-O-acetyl-1-hydroxy-N-methylcanadine 8-hydroxylase
  • EC 1.14.14.168: germacrene A acid 8β-hydroxylase
  • EC 1.14.14.169: eupatolide synthase
  • EC 1.14.14.170: 8-epi-inunolide synthase
  • EC 1.14.14.171: β-amyrin 16α-hydroxylase
  • EC 1.14.14.172: 3,5,6-trichloropyridin-2-ol monooxygenase
  • EC 1.14.14.173: 2,4,6-trichlorophenol monooxygenase
  • EC 1.14.14.174: geranylhydroquinone 3′′-hydroxylase
  • EC 1.14.14.175: ferruginol synthase
  • EC 1.14.14.176: taxadiene 5α-hydroxylase
  • EC 1.14.14.177: ultra-long-chain fatty acid ω-hydroxylase

EC 1.14.15 With reduced iron–sulfur protein as one donor, and incorporation of one atom of oxygen

Most entries from here on have no Wikipedia articles
  • EC 1.14.15.13: pulcherriminic acid synthase
  • EC 1.14.15.14: methyl-branched lipid ω-hydroxylase
  • EC 1.14.15.15: cholestanetriol 26-monooxygenase
  • EC 1.14.15.16: vitamin D3 24-hydroxylase
  • EC 1.14.15.17: pheophorbide a oxygenase
  • EC 1.14.15.18: calcidiol 1-monooxygenase
  • EC 1.14.15.19: C-19 steroid 1α-hydroxylase
  • EC 1.14.15.20: heme oxygenase (biliverdin-producing, ferredoxin)
  • EC 1.14.15.21: zeaxanthin epoxidase
  • EC 1.14.15.22: vitamin D 1,25-hydroxylase
  • EC 1.14.15.23: chloroacetanilide N-alkylformylase
  • EC 1.14.15.24: β-carotene 3-hydroxylase
  • EC 1.14.15.25: p-cymene methyl-monooxygenase
  • EC 1.14.15.26: toluene methyl-monooxygenase
  • EC 1.14.15.27: β-dihydromenaquinone-9 ω-hydroxylase
  • EC 1.14.15.28: cholest-4-en-3-one 26-monooxygenase [(25R)-3-oxocholest-4-en-26-oate forming]
  • EC 1.14.15.29: cholest-4-en-3-one 26-monooxygenase [(25S)-3-oxocholest-4-en-26-oate forming]
  • EC 1.14.15.30: 3-ketosteroid 9α-monooxygenase
  • EC 1.14.15.31: 2-hydroxy-5-methyl-1-naphthoate 7-hydroxylase
  • EC 1.14.15.32: pentalenene oxygenase
  • EC 1.14.15.33: pikromycin synthase
  • EC 1.14.15.34: 20-oxo-5-O-mycaminosyltylactone 23-monooxygenase
  • EC 1.14.15.35: 6-deoxyerythronolide B hydroxylase
  • EC 1.14.15.36: sterol 14α-demethylase (ferredoxin)
  • EC 1.14.15.37: luteothin monooxygenase
  • EC 1.14.15.38: N,N-dimethyl phenylurea N-demethylase
  • EC 1.14.15.39: epi-isozizaene 5-monooxygenase

EC 1.14.16 With reduced pteridine as one donor, and incorporation of one atom of oxygen into the other donor

EC 1.14.17 With reduced ascorbate as one donor, and incorporation of one atom of oxygen into the other donor

EC 1.14.18 With another compound as one donor, and incorporation of one atom of oxygen into the other donor

  • EC 1.14.18.1: tyrosinase
  • EC 1.14.18.2: CMP-N-acetylneuraminate monooxygenase
  • EC 1.14.18.3: methane monooxygenase (particulate)
  • EC 1.14.18.4: phosphatidylcholine 12-monooxygenase *
  • EC 1.14.18.5: sphingolipid C4-monooxygenase *
  • EC 1.14.18.6: 4-hydroxysphinganine ceramide fatty acyl 2-hydroxylase *
  • EC 1.14.18.7: dihydroceramide fatty acyl 2-hydroxylase *
  • EC 1.14.18.8: Now included with EC 1.14.14.139, 5β-cholestane-3α,7α-diol 12α-hydroxylase
  • EC 1.14.18.9: 4α-methylsterol monooxygenase *
  • EC 1.14.18.10: plant 4,4-dimethylsterol C-4α-methyl-monooxygenase *
  • EC 1.14.18.11: plant 4α-monomethylsterol monooxygenase *
  • EC 1.14.18.12: 2-hydroxy fatty acid dioxygenase *
*No Wikipedia article

EC 1.14.19 With oxidation of a pair of donors resulting in the reduction of O2 to two molecules of water

Most of the entries from here on have no Wikipedia articles
  • EC 1.14.19.8: pentalenolactone synthase
  • EC 1.14.19.9: tryptophan 7-halogenase
  • EC 1.14.19.10: icosanoyl-CoA 5-desaturase
  • EC 1.14.19.11: acyl-[acyl-carrier-protein] 4-desaturase
  • EC 1.14.19.12: acyl-lipid ω-(9-4) desaturase
  • EC 1.14.19.13: acyl-CoA 15-desaturase
  • EC 1.14.19.14: linoleoyl-lipid Δ9 conjugase
  • EC 1.14.19.15: (11Z)-hexadec-11-enoyl-CoA conjugase
  • EC 1.14.19.16: linoleoyl-lipid Δ12 conjugase (11E,13Z-forming)
  • EC 1.14.19.17: sphingolipid 4-desaturase
  • EC 1.14.19.18: sphingolipid 8-(E)-desaturase
  • EC 1.14.19.19: sphingolipid 10-desaturase
  • EC 1.14.19.20: Δ7-sterol 5(6)-desaturase
  • EC 1.14.19.21: cholesterol 7-desaturase
  • EC 1.14.19.22: acyl-lipid ω-6 desaturase (cytochrome b5)
  • EC 1.14.19.23: acyl-lipid (n+3)-(Z)-desaturase (ferredoxin)
  • EC 1.14.19.24: acyl-CoA 11-(E)-desaturase
  • EC 1.14.19.25: acyl-lipid ω-3 desaturase (cytochrome b5)
  • EC 1.14.19.26: acyl-[acyl-carrier-protein] 6-desaturase
  • EC 1.14.19.27: sn-2 palmitoyl-lipid 9-desaturase
  • EC 1.14.19.28: sn-1 stearoyl-lipid 9-desaturase
  • EC 1.14.19.29: sphingolipid 8-(E/Z)-desaturase
  • EC 1.14.19.30: acyl-lipid (8-3)-desaturase
  • EC 1.14.19.31: acyl-lipid (7-3)-desaturase
  • EC 1.14.19.32: palmitoyl-CoA 14-(E/Z)-desaturase
  • EC 1.14.19.33: Δ12 acyl-lipid conjugase (11E,13E-forming)
  • EC 1.14.19.34: acyl-lipid (9+3)-(E)-desaturase
  • EC 1.14.19.35: sn-2 acyl-lipid ω-3 desaturase (ferredoxin)
  • EC 1.14.19.36: sn-1 acyl-lipid ω-3 desaturase (ferredoxin)
  • EC 1.14.19.37: acyl-CoA 5-desaturase
  • EC 1.14.19.38: acyl-lipid Δ6-acetylenase
  • EC 1.14.19.39: acyl-lipid Δ12-acetylenase
  • EC 1.14.19.40: hex-5-enoyl-[acyl-carrier protein] acetylenase
  • EC 1.14.19.41: sterol 22-desaturase
  • EC 1.14.19.42: palmitoyl-[glycerolipid] 7-desaturase
  • EC 1.14.19.43: palmitoyl-[glycerolipid] 3-(E)-desaturase
  • EC 1.14.19.44: acyl-CoA (8-3)-desaturase
  • EC 1.14.19.45: sn-1 oleoyl-lipid 12-desaturase
  • EC 1.14.19.46: sn-1 linoleoyl-lipid 6-desaturase
  • EC 1.14.19.47: acyl-lipid (9-3)-desaturase
  • EC 1.14.19.48: tert-amyl alcohol desaturase
  • EC 1.14.19.49: tetracycline 7-halogenase
  • EC 1.14.19.50: noroxomaritidine synthase
  • EC 1.14.19.51: (S)-corytuberine synthase
  • EC 1.14.19.52: camalexin synthase
  • EC 1.14.19.53: all-trans-retinol 3,4-desaturase
  • EC 1.14.19.54: 1,2-dehydroreticuline synthase
  • EC 1.14.19.55: 4-hydroxybenzoate brominase (decarboxylating)
  • EC 1.14.19.56: 1H-pyrrole-2-carbonyl-[peptidyl-carrier protein] chlorinase
  • EC 1.14.19.57: 1H-pyrrole-2-carbonyl-[peptidyl-carrier protein] brominase
  • EC 1.14.19.58: tryptophan 5-halogenase
  • EC 1.14.19.59: tryptophan 6-halogenase
  • EC 1.14.19.60: 7-chloro-L-tryptophan 6-halogenase
  • EC 1.14.19.61: dihydrorhizobitoxine desaturase
  • EC 1.14.19.62: secologanin synthase
  • EC 1.14.19.63: pseudobaptigenin synthase
  • EC 1.14.19.64: (S)-stylopine synthase
  • EC 1.14.19.65: (S)-cheilanthifoline synthase
  • EC 1.14.19.66: berbamunine synthase
  • EC 1.14.19.67: salutaridine synthase
  • EC 1.14.19.68: (S)-canadine synthase
  • EC 1.14.19.69: biflaviolin synthase
  • EC 1.14.19.70: mycocyclosin synthase
  • EC 1.14.19.71: fumitremorgin C synthase
  • EC 1.14.19.72: (–)-pluviatolide synthase
  • EC 1.14.19.73: (S)-nandinine synthase
  • EC 1.14.19.74: (+)-piperitol/(+)-sesamin synthase
  • EC 1.14.19.75: very-long-chain acyl-lipid ω-9 desaturase
  • EC 1.14.19.76: flavone synthase II
  • EC 1.14.19.77: plasmanylethanolamine desaturase
  • EC 1.14.19.78: decanoyl-[acyl-carrier protein] acetylenase

EC 1.14.20 With 2-oxoglutarate as one donor, and the other dehydrogenated

  • EC 1.14.20.1: deacetoxycephalosporin-C synthase
  • EC 1.14.20.2: Now EC 1.14.11.59, 2,4-dihydroxy-1,4-benzoxazin-3-one-glucoside dioxygenase
  • EC 1.14.20.3: (5R)-carbapenem-3-carboxylate synthase *
  • EC 1.14.20.4: anthocyanidin synthase *
  • EC 1.14.20.5: flavone synthase I *
  • EC 1.14.20.6: flavonol synthase *
  • EC 1.14.20.7: 2-oxoglutarate/L-arginine monooxygenase/decarboxylase (succinate-forming) *
  • EC 1.14.20.8: (–)-deoxypodophyllotoxin synthase *
  • EC 1.14.20.9: L-tyrosine isonitrile desaturase *
  • EC 1.14.20.10: L-tyrosine isonitrile desaturase/decarboxylase *
  • EC 1.14.20.11: 3-[(Z)-2-isocyanoethenyl]-1H-indole synthase *
  • EC 1.14.20.12: 3-[(E)-2-isocyanoethenyl]-1H-indole synthase *
  • EC 1.14.20.13: 6β-hydroxyhyoscyamine epoxidase *
  • EC 1.14.20.14: hapalindole-type alkaloid chlorinase *
  • EC 1.14.20.15: L-threonyl-[L-threonyl-carrier protein] 4-chlorinase *
*No Wikipedia article

EC 1.14.21 With NADH or NADPH as one donor, and the other dehydrogenated

  • EC 1.14.21.1: Now EC 1.14.19.64, (S)-stylopine synthase
  • EC 1.14.21.2: Now EC 1.14.19.65, (S)-cheilanthifoline synthase
  • EC 1.14.21.3: Now EC 1.14.19.66, berbamunine synthase
  • EC 1.14.21.4: Now EC 1.14.19.67, salutaridine synthase
  • EC 1.14.21.5: Now EC 1.14.19.68, (S)-canadine synthase
  • EC 1.14.21.6: Now EC 1.14.19.20, Δ7-sterol 5(6)-desaturase
  • EC 1.14.21.7: Now EC 1.14.19.69, biflaviolin synthase
  • EC 1.14.21.8: Now EC 1.14.19.63, pseudobaptigenin synthase
  • EC 1.14.21.9: Now EC 1.14.19.70, mycocyclosin synthase *
  • EC 1.14.21.10: Now EC 1.14.19.71, fumitremorgin C synthase *
  • EC 1.14.21.11: Now EC 1.14.19.72, (–)-pluviatolide synthase *
  • EC 1.14.21.12: Now EC 1.14.19.73, (S)-nandinine synthase *
*No Wikipedia article

EC 1.14.99 Miscellaneous

Most of the entries from here on have no Wikipedia article
  • EC 1.14.99.48: heme oxygenase (staphylobilin-producing)
  • EC 1.14.99.49: Now EC 1.14.15.31, 2-hydroxy-5-methyl-1-naphthoate 7-hydroxylase
  • EC 1.14.99.50: γ-glutamyl hercynylcysteine S-oxide synthase
  • EC 1.14.99.51: hercynylcysteine S-oxide synthase
  • EC 1.14.99.52: L-cysteinyl-L-histidinylsulfoxide synthase
  • EC 1.14.99.53: lytic chitin monooxygenase
  • EC 1.14.99.54: lytic cellulose monooxygenase (C1-hydroxylating)
  • EC 1.14.99.55: lytic starch monooxygenase
  • EC 1.14.99.56: lytic cellulose monooxygenase (C4-dehydrogenating)
  • EC 1.14.99.57: heme oxygenase (mycobilin-producing)
  • EC 1.14.99.58: heme oxygenase (biliverdin-IX-β and δ-forming)
  • EC 1.14.99.59: tryptamine 4-monooxygenase
  • EC 1.14.99.60: 3-demethoxyubiquinol 3-hydroxylase
  • EC 1.14.99.61: cyclooctat-9-en-7-ol 5-monooxygenase
  • EC 1.14.99.62: cyclooctatin synthase
  • EC 1.14.99.63: β-carotene 4-ketolase
  • EC 1.14.99.64: zeaxanthin 4-ketolase
  • EC 1.14.99.65: 4-amino-L-phenylalanyl-[CmlP-peptidyl-carrier-protein] 3-hydroxylase
  • EC 1.14.99.66: [histone H3]-N 6,N 6-dimethyl-L-lysine4 FAD-dependent demethylase
  • EC 1.14.99.67: α-N-dichloroacetyl-p-aminophenylserinol N-oxygenase
  • EC 1.14.99.68: 4-aminobenzoate N-oxygenase
  • EC 1.14.99.69: tRNA 2-(methylsulfanyl)-N 6-isopentenyladenosine37 hydroxylase

EC 1.15 Acting on superoxide as acceptor

EC 1.15.1

EC 1.16 Oxidizing metal ions

EC 1.16.1 With NAD+ or NADP+ as acceptor

*No Wikipedia article

EC 1.16.3 With oxygen as acceptor

  • EC 1.16.3.1: ferroxidase
  • EC 1.16.3.2: bacterial non-heme ferritin *
  • EC 1.16.3.3: manganese oxidase *
*No Wikipedia article

EC 1.16.5 With a quinone or similar compound as acceptor

  • EC 1.16.5.1: Now EC 7.2.1.3, ascorbate ferrireductase (transmembrane)

EC 1.16.8 With a flavin as acceptor

  • EC 1.16.8.1: activity now known to be catalyzed by EC 2.5.1.17, corrinoid adenosyltransferase

EC 1.16.9 With a copper protein as acceptor

EC 1.16.98 With other, known, physiological acceptors

  • EC 1.16.98.1: Now EC 1.16.9.1 iron:rusticyanin reductase

EC 1.16.99 With unknown physiological acceptors

  • EC 1.16.99.1: [Co(II) methylated amine-specific corrinoid protein] reductase

EC 1.17 Acting on CH or CH2 groups

EC 1.17.1 With NAD or NADP as acceptor

  • EC 1.17.1.1: CDP-4-dehydro-6-deoxyglucose reductase
  • EC 1.17.1.2: now classified as EC 1.17.7.4, 4-hydroxy-3-methylbut-2-enyl diphosphate reductase
  • EC 1.17.1.3: leucoanthocyanidin reductase
  • EC 1.17.1.4: xanthine dehydrogenase
  • EC 1.17.1.5: nicotinate dehydrogenase
  • EC 1.17.1.6: Now EC 1.17.99.5, bile-acid 7α-dehydroxylase. It is now known that FAD is the acceptor and not NAD+ as was thought previously
  • EC 1.17.1.7: Now EC 1.2.1.91, 3-oxo-5,6-dehydrosuberyl-CoA semialdehyde dehydrogenase
  • EC 1.17.1.8: 4-hydroxy-tetrahydrodipicolinate reductase *
  • EC 1.17.1.9: formate dehydrogenase *
  • EC 1.17.1.10: formate dehydrogenase (NADP+) *
  • EC 1.17.1.11: formate dehydrogenase (NAD+, ferredoxin) *
*No Wikipedia article

EC 1.17.2 With a cytochrome as acceptor

*No Wikipedia article

EC 1.17.3 With oxygen as acceptor

*No Wikipedia article

EC 1.17.4 With a disulfide as acceptor

*No Wikipedia article

EC 1.17.5 With a quinone or similar compound as acceptor

*No Wikipedia article

EC 1.17.7 With an iron–sulfur protein as acceptor

*No Wikipedia article

EC 1.17.98 With other, known, physiological acceptors

  • EC 1.17.98.1: bile-acid 7α-dehydroxylase. Now known to be catalyzed by multiple enzymes.
  • EC 1.17.98.2: bacteriochlorophyllide c C-71-hydroxylase *
  • EC 1.17.98.3: formate dehydrogenase (coenzyme F420) *
  • EC 1.17.98.4: formate dehydrogenase (hydrogenase) *
*No Wikipedia article

EC 1.17.99 With unknown physiological acceptors

No Wikipedia article for any of these
  • EC 1.17.99.1: Now EC 1.17.9.1, 4-methylphenol dehydrogenase (hydroxylating)
  • EC 1.17.99.2: ethylbenzene hydroxylase
  • EC 1.17.99.3: 3α,7α,12α-trihydroxy-5β-cholestanoyl-CoA 24-hydroxylase
  • EC 1.17.99.4: uracil/thymine dehydrogenase
  • EC 1.17.99.5: Now classified as EC 1.17.98.1, bile-acid 7α-dehydroxylase
  • EC 1.17.99.6: epoxyqueuosine reductase
  • EC 1.17.99.7: Now classified as EC 1.17.98.4, formate dehydrogenase (hydrogenase)
  • EC 1.17.99.8: limonene dehydrogenase
  • EC 1.17.99.9: heme a synthase
  • EC 1.17.99.10: steroid C-25 hydroxylase
  • EC 1.17.99.11: 3-oxo-Δ1-steroid hydratase/dehydrogenase

EC 1.18 Acting on iron–sulfur proteins as donors

EC 1.18.1 With NAD+ or NADP+ as acceptor

EC 1.18.2 With dinitrogen as acceptor (deleted sub-subclass)

  • EC 1.18.2.1: now EC 1.18.6.1, nitrogenase

EC 1.18.3 With H+ as acceptor (deleted sub-subclass)

  • EC 1.18.3.1: Now EC 1.12.7.2, ferredoxin hydrogenase

EC 1.18.6 With dinitrogen as acceptor

*No Wikipedia article

EC 1.18.96 With other, known, acceptors (deleted sub-subclass)

  • EC 1.18.96.1: Now EC 1.15.1.2, superoxide reductase

EC 1.18.99 With H+ as acceptor (deleted sub-subclass)

  • EC 1.18.99.1: Now EC 1.12.7.2, ferredoxin hydrogenase

EC 1.19 Acting on reduced flavodoxin as donor

EC 1.19.1 With NAD+ or NADP+ as acceptor

  • EC 1.19.1.1: flavodoxin—NADP+ reductase

EC 1.19.6 With dinitrogen as acceptor

EC 1.20 Acting on phosphorus or arsenic in donors

EC 1.20.1 Acting on phosphorus or arsenic in donors, with NAD+ as acceptor

EC 1.20.2 Acting on phosphorus or arsenic in donors, with NAD(P)+ as acceptor

EC 1.20.4 Acting on phosphorus or arsenic in donors, with disulfide as acceptor

*No Wikipedia article

EC 1.20.9 With a copper protein as acceptor

EC 1.20.98 With other, known acceptors

  • EC 1.20.98.1: Now EC 1.20.9.1, arsenate reductase (azurin)

EC 1.20.99 With unknown physiological acceptors

EC 1.21 Catalysing the reaction X-H + Y-H = X-Y

EC 1.21.3 With oxygen as acceptor

EC 1.21.4 With a disulfide as acceptor

*No Wikipedia article

EC 1.21.98 With other, known, physiological acceptors

  • EC 1.21.98.1: cyclic dehypoxanthinyl futalosine synthase *
  • EC 1.21.98.2: dichlorochromopyrrolate synthase *
  • EC 1.21.98.3: anaerobic magnesium-protoporphyrin IX monomethyl ester cyclase *
  • EC 1.21.98.4: PqqA peptide cyclase *
*No Wikipedia article

EC 1.21.99 With unknown physiological acceptors

  • EC 1.21.99.1 EC 1.21.99.1: β-cyclopiazonate dehydrogenase
  • EC 1.21.99.2: Now classified as EC 1.21.98.1, cyclic dehypoxanthinyl futalosine synthase.
  • EC 1.21.99.3: thyroxine 5-deiodinase *
  • EC 1.21.99.4: thyroxine 5′-deiodinase *
  • EC 1.21.99.5: tetrachloroethene reductive dehalogenase *
*No Wikipedia article

EC 1.22 Acting on halogen in donors

EC 1.22.1 With NAD+ or NADP+ as acceptor

  • EC 1.22.1.1: Now EC 1.21.1.1, iodotyrosine deiodinase

EC 1.23 Reducing C-O-C group as acceptor

EC 1.23.1 With NADH or NADPH as donor

  • EC 1.23.1.1: (+)-pinoresinol reductase *
  • EC 1.23.1.2: (+)-lariciresinol reductase *
  • EC 1.23.1.3: (–)-pinoresinol reductase *
  • EC 1.23.1.4: (–)-lariciresinol reductase *
*No Wikipedia article

EC 1.97 Other oxidoreductases

EC 1.97.1 Sole sub-subclass for oxidoreductases that do not belong in the other subclasses

EC 1.98 Enzymes using H2 as reductant (deleted subclass)

EC 1.98.1.1: Now EC 1.12.7.2, ferredoxin hydrogenase

EC 1.99 Other enzymes using O2 as oxidant

EC 1.99.1 Hydroxylases (now covered by EC 1.14)

  • EC 1.99.1.1: deleted, Now EC 1.12.7.2, ferredoxin hydrogenase
  • EC 1.99.1.2: deleted, Now EC 1.14.16.1, phenylalanine 4-monooxygenase
  • EC 1.99.1.3: deleted, nicotinate 6-hydroxylase
  • EC 1.99.1.4: deleted, tryptophan 5-hydroxylase
  • EC 1.99.1.5: deleted, Now EC 1.14.13.9, kynurenine 3-monooxygenase
  • EC 1.99.1.6: deleted, steroid 11α-hydroxylase
  • EC 1.99.1.7: deleted, Now EC 1.14.15.4, steroid 11β-monooxygenase
  • EC 1.99.1.8: deleted, steroid 6β-hydroxylase
  • EC 1.99.1.9: deleted, Now EC 1.14.99.9, steroid 17α-monooxygenase
  • EC 1.99.1.10: deleted, steroid 19-hydroxylase
  • EC 1.99.1.11: deleted, Now EC 1.14.99.10, steroid 21-monooxygenase
  • EC 1.99.1.12: deleted, alkoxyaryl hydroxylase
  • EC 1.99.1.13: deleted, covered by EC 1.14.99.7 (squalene monooxygenase) and by EC 5.4.99.7 (lanosterol synthase)
  • EC 1.99.1.14: deleted, Now EC 1.13.11.27, 4-hydroxyphenylpyruvate dioxygenase

EC 1.99.2 Oxygenases (now covered by EC 1.13)

  • EC 1.99.2.1: deleted, now EC 1.13.11.12, lipoxygenase
  • EC 1.99.2.2: deleted, now EC 1.13.11.1, catechol 1,2-dioxygenase
  • EC 1.99.2.3: deleted, now EC 1.13.11.3, protocatechuate 3,4-dioxygenase
  • EC 1.99.2.4: deleted, now EC 1.13.11.4, gentisate 1,2-dioxygenase
  • EC 1.99.2.5: deleted, now EC 1.13.11.5, homogentisate 1,2-dioxygenase
  • EC 1.99.2.6: deleted, now EC 1.13.99.1, inositol oxygenase

References

  1. ^ "ExplorEnz – The Enzyme Database".
  2. ^ McDonald, A.G.; Boyce, S.; K.F., Tipton (2009). "ExplorEnz: the primary source of the IUBMB enzyme list". Nucleic Acids Res. 37 (Database issue): D593–D597. doi:10.1093/nar/gkn582. PMC 2686581. PMID 18776214.
Retrieved from "https://en.wikipedia.org/w/index.php?title=List_of_EC_numbers_(EC_1)&oldid=1205571777#EC_1.1_Acting_on_the_CH-OH_group_of_donors"