Protein-coding gene in the species Homo sapiens
GPX8 |
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Available structures |
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PDB | Ortholog search: PDBe RCSB |
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List of PDB id codes |
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3CYN, 3KIJ |
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Identifiers |
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Aliases | GPX8, EPLA847, GPx-8, GSHPx-8, UNQ847, glutathione peroxidase 8 (putative) |
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External IDs | OMIM: 617172 MGI: 1916840 HomoloGene: 88454 GeneCards: GPX8 |
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Gene location (Mouse) |
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| Chr. | Chromosome 13 (mouse)[2] |
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| Band | 13|13 D2.2 | Start | 113,179,287 bp[2] |
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End | 113,182,944 bp[2] |
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RNA expression pattern |
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Bgee | Human | Mouse (ortholog) |
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Top expressed in | - stromal cell of endometrium
- tibia
- germinal epithelium
- placenta
- smooth muscle tissue
- Achilles tendon
- parietal pleura
- synovial membrane
- corpus epididymis
- pericardium
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| Top expressed in | - calvaria
- belly cord
- interventricular septum
- uterus
- intercostal muscle
- cervix
- body of femur
- molar
- dermis
- fossa
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| More reference expression data |
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BioGPS | |
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Gene ontology |
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Molecular function |
- oxidoreductase activity
- glutathione peroxidase activity
- peroxidase activity
| Cellular component |
- integral component of membrane
- endoplasmic reticulum lumen
- membrane
| Biological process |
- response to oxidative stress
- cellular oxidant detoxification
- cellular response to oxidative stress
| Sources:Amigo / QuickGO |
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Orthologs |
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Species | Human | Mouse |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (mRNA) | |
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NM_001008397 NM_001306197 NM_001306198 NM_001306201 |
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RefSeq (protein) | |
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NP_001008398 NP_001293126 NP_001293127 NP_001293130 |
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Location (UCSC) | Chr 5: 55.16 – 55.17 Mb | Chr 13: 113.18 – 113.18 Mb |
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PubMed search | [3] | [4] |
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Wikidata |
View/Edit Human | View/Edit Mouse |
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Glutathione peroxidase 8 (GPx-8) is an enzyme that in humans is encoded by the GPX8 gene.[5][6] GPx-8 is a member of the glutathione peroxidase family.
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000164294 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000021760 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Entrez Gene: glutathione peroxidase 8 (putative)".
- ^ Toppo S, Vanin S, Bosello V, Tosatto SC (September 2008). "Evolutionary and structural insights into the multifaceted glutathione peroxidase (Gpx) superfamily". Antioxid. Redox Signal. 10 (9): 1501–14. doi:10.1089/ars.2008.2057. PMID 18498225.
External links
- PDBe-KB provides an overview of all the structure information available in the PDB for Human Glutathione Peroxidase 8 (GPX8)
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Regulation | |
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Classification | |
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Kinetics | |
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