XAB2

XAB2
Identifiers
Aliases	XAB2, HCNP, HCRN, NTC90, SYF1, XPA binding protein 2
External IDs	OMIM: 610850; MGI: 1914689; HomoloGene: 5738; GeneCards: XAB2; OMA:XAB2 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	7,629,545 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	3,671,316 bp
RNA expression pattern
	Top expressed in
	left ovary; ; granulocyte; ; right ovary; ; skin of leg; ; body of uterus; ; right uterine tube; ; canal of the cervix; ; right lobe of thyroid gland; ; left lobe of thyroid gland; ; skin of abdomen;
	Top expressed in
	gastrula; ; submandibular gland; ; internal carotid artery; ; external carotid artery; ; Rostral migratory stream; ; Gonadal ridge; ; vestibular membrane of cochlear duct; ; maxillary prominence; ; epiblast; ; granulocyte;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding;
Cellular component	catalytic step 2 spliceosome; membrane; nucleoplasm; spliceosomal complex; nucleus; Prp19 complex; prespliceosome; catalytic step 1 spliceosome; post-mRNA release spliceosomal complex; U2-type catalytic step 2 spliceosome;
Biological process	RNA processing; mRNA processing; transcription, DNA-templated; cellular response to DNA damage stimulus; RNA splicing; cerebral cortex development; transcription-coupled nucleotide-excision repair; blastocyst development; DNA repair; mRNA splicing, via spliceosome; generation of catalytic spliceosome for first transesterification step;
	Sources:Amigo / QuickGO
Orthologs
	56949
	67439
	ENSG00000076924
	ENSMUSG00000019470
	Q9HCS7
	Q9DCD2
	NM_020196
	NM_026156
	NP_064581
	NP_080432
	Wikidata
View/Edit Human	View/Edit Mouse

Pre-mRNA-splicing factor SYF1 is a protein that in humans is encoded by the XAB2 gene.^[5]^[6]

Interactions

XAB2 has been shown to interact with ERCC8^[5] and XPA.^[5]

References

^ a b c GRCh38: Ensembl release 89: ENSG00000076924 – Ensembl, May 2017
^ a b c GRCm38: Ensembl release 89: ENSMUSG00000019470 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ a b c Nakatsu Y, Asahina H, Citterio E, Rademakers S, Vermeulen W, Kamiuchi S, Yeo JP, Khaw MC, Saijo M, Kodo N, Matsuda T, Hoeijmakers JH, Tanaka K (Nov 2000). "XAB2, a novel tetratricopeptide repeat protein involved in transcription-coupled DNA repair and transcription". J. Biol. Chem. 275 (45): 34931–7. doi:10.1074/jbc.M004936200. hdl:1765/3168. PMID 10944529.
^ "Entrez Gene: XAB2 XPA binding protein 2".

Hirosawa M, Nagase T, Ishikawa K, Kikuno R, Nomura N, Ohara O (1999). "Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain". DNA Res. 6 (5): 329–36. doi:10.1093/dnares/6.5.329. PMID 10574461.
Jurica MS, Licklider LJ, Gygi SR, Grigorieff N, Moore MJ (2002). "Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis". RNA. 8 (4): 426–39. doi:10.1017/S1355838202021088. PMC 1370266. PMID 11991638.
Colland F, Jacq X, Trouplin V, Mougin C, Groizeleau C, Hamburger A, Meil A, Wojcik J, Legrain P, Gauthier JM (2004). "Functional proteomics mapping of a human signaling pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
Wan D, Gong Y, Qin W, Zhang P, Li J, Wei L, Zhou X, Li H, Qiu X, Zhong F, He L, Yu J, Yao G, Jiang H, Qian L, Yu Y, Shu H, Chen X, Xu H, Guo M, Pan Z, Chen Y, Ge C, Yang S, Gu J (2004). "Large-scale cDNA transfection screening for genes related to cancer development and progression". Proc. Natl. Acad. Sci. U.S.A. 101 (44): 15724–9. Bibcode:2004PNAS..10115724W. doi:10.1073/pnas.0404089101. PMC 524842. PMID 15498874.

This article on a gene on human chromosome 19 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000076924 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000019470 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10944529-5] Nakatsu Y, Asahina H, Citterio E, Rademakers S, Vermeulen W, Kamiuchi S, Yeo JP, Khaw MC, Saijo M, Kodo N, Matsuda T, Hoeijmakers JH, Tanaka K (Nov 2000). "XAB2, a novel tetratricopeptide repeat protein involved in transcription-coupled DNA repair and transcription". J. Biol. Chem. 275 (45): 34931–7. doi:10.1074/jbc.M004936200. hdl:1765/3168. PMID 10944529.

[entrez-6] "Entrez Gene: XAB2 XPA binding protein 2".

XAB2

Interactions

References

Further reading