User:Mr. Ibrahem/Sertraline
Clinical data | |
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Pronunciation | /ˈsərtrəˌliːn/ |
Trade names | Zoloft and others[1] |
AHFS/Drugs.com | Monograph |
MedlinePlus | a697048 |
License data |
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Pregnancy category |
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Addiction liability | None[3] |
Routes of administration | By mouth (tablets and solution) |
Drug class | Selective serotonin reuptake inhibitor |
Legal status | |
Legal status | |
Pharmacokinetic data | |
Bioavailability | 44% |
Protein binding | 98.5% |
Metabolism | Liver (N-demethylation mainly by CYP2B6)[9] |
Metabolites | Norsertraline |
Elimination half-life | ~23–26 h (66 h [less-active[4] metabolite, norsertraline])[5][6][7][8] |
Excretion | Kidney |
Identifiers | |
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Chemical and physical data | |
Formula | C17H17Cl2N |
Molar mass | 306.23 g·mol−1 |
3D model (JSmol) |
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Sertraline, sold under the brand name Zoloft among others, is an antidepressant of the selective serotonin reuptake inhibitor (SSRI) class.[12] It is used to treat major depressive disorder, obsessive–compulsive disorder, panic disorder, post-traumatic stress disorder, premenstrual dysphoric disorder, and social anxiety disorder.[12] Sertraline is taken by mouth.[12]
Common side effects include diarrhea, sexual dysfunction, and troubles with sleep.[12] Serious side effects include an increased risk of suicide in those less than 25 years old and serotonin syndrome.[12] It is unclear whether use during pregnancy or breastfeeding is safe.[13] It should not be used together with MAO inhibitor medication.[12] Sertraline is believed to work by increasing serotonin effects in the brain.[12]
Sertraline was approved for medical use in the United States in 1991 and initially sold by Pfizer.[12] It is on the World Health Organization's List of Essential Medicines as an alternative to fluoxetine.[14] It is available as a generic medication.[12] In the United States, the wholesale cost is about US$1.50 per month as of 2018.[15] In 2016, it was the most commonly prescribed psychiatric medication in the United States,[16] with over 37 million prescriptions.[17] In 2017, it was the 14th most commonly prescribed medication in the United States with over 38 million prescriptions.[18][17]
References
- ^ "Sertraline". Drugs.com. Archived from the original on 9 May 2015. Retrieved 11 May 2015.
- ^ a b "Sertraline (Zoloft) Use During Pregnancy". Drugs.com. 4 May 2020. Archived from the original on 20 June 2020. Retrieved 17 May 2020.
- ^ Hubbard, John R.; Martin, Peter R. (2001). Substance Abuse in the Mentally and Physically Disabled. CRC Press. p. 26. ISBN 9780824744977. Archived from the original on 1 August 2020. Retrieved 8 August 2020.
- ^ Sertraline FDA Label Wayback Machine at the Wayback Machine (archived 30 October 2020) Last updated May 2014
- ^ Brunton L, Chabner B, Knollman B. (2010) Goodman and Gilman’s The Pharmacological Basis of Therapeutics, Twelfth Edition. McGraw Hill Professional. ISBN 9780071769396
- ^ Obach RS, Walsky RL, Venkatakrishnan K, Gaman EA, Houston JB, Tremaine LM (January 2006). "The utility of in vitro cytochrome P450 inhibition data in the prediction of drug-drug interactions". The Journal of Pharmacology and Experimental Therapeutics. 316 (1): 336–48. doi:10.1124/jpet.105.093229. PMID 16192315. S2CID 12975686.
- ^ DeVane CL, Liston HL, Markowitz JS (2002). "Clinical pharmacokinetics of sertraline". Clinical Pharmacokinetics. 41 (15): 1247–66. doi:10.2165/00003088-200241150-00002. PMID 12452737. S2CID 28720641.
- ^ DeVane CL, Donovan JL, Liston HL, Markowitz JS, Cheng KT, Risch SC, Willard L (February 2004). "Comparative CYP3A4 inhibitory effects of venlafaxine, fluoxetine, sertraline, and nefazodone in healthy volunteers". Journal of Clinical Psychopharmacology. 24 (1): 4–10. doi:10.1097/01.jcp.0000104908.75206.26. PMID 14709940. S2CID 25826168.
- ^ Cite error: The named reference
pmid15547048
was invoked but never defined (see the help page). - ^ "SERTRALINE oral - Essential drugs". medicalguidelines.msf.org. Archived from the original on 29 August 2021. Retrieved 24 August 2020.
- ^ "WHOCC - ATC/DDD Index". www.whocc.no. Archived from the original on 20 September 2020. Retrieved 9 September 2020.
- ^ a b c d e f g h i "Sertraline Hydrochloride". Drugs.com. The American Society of Health-System Pharmacists. Archived from the original on 18 March 2019. Retrieved 8 January 2018.
- ^ "Sertraline (Zoloft) Use During Pregnancy". Drugs.com. Archived from the original on 20 June 2020. Retrieved 7 January 2018.
- ^ World Health Organization (2023). The selection and use of essential medicines 2023: web annex A: World Health Organization model list of essential medicines: 23rd list (2023). Geneva: World Health Organization. hdl:10665/371090. WHO/MHP/HPS/EML/2023.02.
- ^ "NADAC as of 2018-01-03". Centers for Medicare and Medicaid Services. Archived from the original on 24 June 2019. Retrieved 7 January 2018.
- ^ Grohol, John M. (12 October 2017). "Top 25 Psychiatric Medications for 2016". Psych Central. Archived from the original on 20 September 2020. Retrieved October 22, 2018.
- ^ a b "Sertraline Hydrochloride - Drug Usage Statistics". ClinCalc. 23 December 2019. Archived from the original on 11 April 2020. Retrieved 11 April 2020.
- ^ "The Top 300 of 2020". ClinCalc. Archived from the original on 18 March 2020. Retrieved 11 April 2020.