User:Mr. Ibrahem/Ceftaroline fosamil

Mr. Ibrahem/Ceftaroline fosamil
Space-filling model of the ceftaroline fosamil molecule as a zwitterion
Clinical data
Pronunciation/sɛfˈtæroʊliːn/
Trade namesTeflaro, Zinforo
Other namesCeftaroline, PPI 0903, TAK-599
AHFS/Drugs.comMonograph
MedlinePlusa611014
License data
  • EU EMA: by INN
  • US DailyMed: Ceftaroline_fosamil
  • US FDA: Ceftaroline
Pregnancy
category
  • AU: B1
Routes of
administration		Intravenous
Drug classCephalosporin[1]
Legal status
Legal status
  • AU: S4 (Prescription only)
  • US: ℞-only[1]
  • EU: Rx-only[2]
Pharmacokinetic data
Protein binding20%
Elimination half-life2.5 hours
ExcretionUrine (88%), faeces (6%)
Identifiers
  • (6R,7R)-7-[(2Z)-2-ethoxyimino-2-[5-(phosphonoamino)-1,2,4-thiadiazol-3-yl]acetyl]amino]-3-[4-(1-methylpyridin-1-ium-4-yl)-1,3-thiazol-2-yl]sulfanyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
Chemical and physical data
FormulaC22H21N8O8PS4
Molar mass684.67 g·mol−1
3D model (JSmol)
  • Interactive image
  • O=C4N3/C(=C(/Sc2nc(c1cc[n+](cc1)C)cs2)CS[C@@H]3[C@@H]4NC(=O)C(=N\OCC)/c5nc(sn5)NP(=O)(O)O)C([O-])=O
  • InChI=1S/C22H21N8O8PS4/c1-3-38-26-13(16-25-21(43-28-16)27-39(35,36)37)17(31)24-14-18(32)30-15(20(33)34)12(9-40-19(14)30)42-22-23-11(8-41-22)10-4-6-29(2)7-5-10/h4-8,14,19H,3,9H2,1-2H3,(H4-,24,25,27,28,31,33,34,35,36,37)/b26-13-/t14-,19-/m1/s1 ☒N
  • Key:ZCCUWMICIWSJIX-NQJJCJBVSA-N ☒N
 ☒NcheckY (what is this?)  (verify)

Ceftaroline fosamil, sold under the brand name Teflaro and Zinforo, is an antibioticused to treat skin and soft tissue infections and pneumonia.[1][2] It is used in difficult to treat cases including those with methicillin-resistant Staphylococcus aureus (MRSA).[2][4] It is given by injection into a vein.[3]

Common side effects include diarrhea, nausea, rash, and fever.[1] Other side effects may include anaphylaxis, Clostridioides difficile infection, and red blood cell breakdown.[1] Well there is no evidence of harm in pregnancy, such use has not been well studied.[5] It is a cephalosporin and works by disrupting the bacterial cell wall.[1][2]

Ceftaroline was approved for medical use in the United States in 2010 and Europe in 2012.[4][2] It was removed from the World Health Organization's List of Essential Medicines in 2019.[6] In the United Kingdom 5 days of treatment costs the NHS about £375 as of 2021.[3] This amount in the United States costa bout 2,200 USD.[7]

References

  1. ^ a b c d e f g h "Teflaro- ceftaroline fosamil powder, for solution". DailyMed. 24 September 2019. Archived from the original on 18 January 2021. Retrieved 1 March 2020.
  2. ^ a b c d e f "Zinforo EPAR". European Medicines Agency (EMA). Archived from the original on 12 July 2019. Retrieved 1 March 2020.
  3. ^ a b c BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 562. ISBN 978-0857114105.
  4. ^ a b "Ceftaroline Monograph for Professionals". Drugs.com. Archived from the original on 23 January 2021. Retrieved 1 January 2022.
  5. ^ "Ceftaroline (Teflaro) Use During Pregnancy". Drugs.com. Archived from the original on 28 November 2020. Retrieved 2 January 2022.
  6. ^ World Health Organization (2019). Executive summary: the selection and use of essential medicines 2019: report of the 22nd WHO Expert Committee on the selection and use of essential medicines. Geneva: World Health Organization. hdl:10665/325773. WHO/MVP/EMP/IAU/2019.05. License: CC BY-NC-SA 3.0 IGO.
  7. ^ "Teflaro Prices, Coupons & Patient Assistance Programs". Drugs.com. Archived from the original on 11 November 2020. Retrieved 2 January 2022.
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