TOMM22

TOMM22
Identifiers
Aliases	TOMM22, 1C9-2, MST065, MSTP065, TOM22, translocase of outer mitochondrial membrane 22
External IDs	OMIM: 607046 MGI: 2450248 HomoloGene: 10638 GeneCards: TOMM22
Gene location (Human)
Chr.	Chromosome 22 (human)
End	38,685,421 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	79,557,601 bp
RNA expression pattern
	Top expressed in
	rectum; ; ganglionic eminence; ; internal globus pallidus; ; monocyte; ; prefrontal cortex; ; islet of Langerhans; ; right adrenal gland; ; left adrenal gland; ; gastrocnemius muscle; ; left ventricle;
	Top expressed in
	spermatid; ; spermatocyte; ; morula; ; neural tube; ; mesencephalon; ; ileum; ; ganglionic eminence; ; testicle; ; jejunum; ; duodenum;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein transmembrane transporter activity; protein binding;
Cellular component	mitochondrial outer membrane translocase complex; integral component of membrane; mitochondrial inner membrane; mitochondrial outer membrane; integral component of mitochondrial outer membrane; membrane; mitochondrion;
Biological process	protein transport; protein targeting to mitochondrion; protein import into mitochondrial matrix; intracellular protein transport; protein insertion into mitochondrial outer membrane; macroautophagy; transport; positive regulation of apoptotic process; protein insertion into mitochondrial membrane; protein transmembrane transport;
	Sources:Amigo / QuickGO
Orthologs
	56993
	223696
	ENSG00000100216
	ENSMUSG00000022427
	Q9NS69
	Q9CPQ3
	NM_020243
	NM_172609
	NP_064628
	NP_766197
	Wikidata
View/Edit Human	View/Edit Mouse

Mitochondrial import receptor subunit TOM22 homolog (hTom22) is a protein that in humans is encoded by the TOMM22 gene.^[5]^[6]^[7]

The protein encoded by this gene is an integral membrane protein of the outer mitochondrial membrane. The encoded protein interacts with TOMM20 and TOMM40, and with other proteins forms a complex – the translocase of the outer membrane, to import cytosolic preproteins into the mitochondrion.^[7]

References

^ a b c GRCh38: Ensembl release 89: ENSG00000100216 – Ensembl, May 2017
^ a b c GRCm38: Ensembl release 89: ENSMUSG00000022427 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Yano M, Hoogenraad N, Terada K, Mori M (Oct 2000). "Identification and functional analysis of human Tom22 for protein import into mitochondria". Mol Cell Biol. 20 (19): 7205–13. doi:10.1128/MCB.20.19.7205-7213.2000. PMC 86274. PMID 10982837.
^ Saeki K, Suzuki H, Tsuneoka M, Maeda M, Iwamoto R, Hasuwa H, Shida S, Takahashi T, Sakaguchi M, Endo T, Miura Y, Mekada E, Mihara K (Nov 2000). "Identification of mammalian TOM22 as a subunit of the preprotein translocase of the mitochondrial outer membrane". J Biol Chem. 275 (41): 31996–2002. doi:10.1074/jbc.M004794200. PMID 10900208.
^ a b "Entrez Gene: TOMM22 translocase of outer mitochondrial membrane 22 homolog (yeast)".

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Suzuki H, Okazawa Y, Komiya T, et al. (2001). "Characterization of rat TOM40, a central component of the preprotein translocase of the mitochondrial outer membrane". J. Biol. Chem. 275 (48): 37930–6. doi:10.1074/jbc.M006558200. PMID 10980201.
Johnston AJ, Hoogenraad J, Dougan DA, et al. (2003). "Insertion and assembly of human tom7 into the preprotein translocase complex of the outer mitochondrial membrane". J. Biol. Chem. 277 (44): 42197–204. doi:10.1074/jbc.M205613200. PMID 12198123.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Yano M, Terada K, Mori M (2003). "AIP is a mitochondrial import mediator that binds to both import receptor Tom20 and preproteins". J. Cell Biol. 163 (1): 45–56. doi:10.1083/jcb.200305051. PMC 2173431. PMID 14557246.
Yano M, Terada K, Mori M (2004). "Mitochondrial import receptors Tom20 and Tom22 have chaperone-like activity". J. Biol. Chem. 279 (11): 10808–13. doi:10.1074/jbc.M311710200. PMID 14699115.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Collins JE, Wright CL, Edwards CA, et al. (2005). "A genome annotation-driven approach to cloning the human ORFeome". Genome Biol. 5 (10): R84. doi:10.1186/gb-2004-5-10-r84. PMC 545604. PMID 15461802.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Humphries AD, Streimann IC, Stojanovski D, et al. (2005). "Dissection of the mitochondrial import and assembly pathway for human Tom40". J. Biol. Chem. 280 (12): 11535–43. doi:10.1074/jbc.M413816200. PMID 15644312.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
Bellot G, Cartron PF, Er E, et al. (2007). "TOM22, a core component of the mitochondria outer membrane protein translocation pore, is a mitochondrial receptor for the proapoptotic protein Bax". Cell Death Differ. 14 (4): 785–94. doi:10.1038/sj.cdd.4402055. PMID 17096026.

This article on a gene on human chromosome 22 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000100216 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000022427 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10982837-5] Yano M, Hoogenraad N, Terada K, Mori M (Oct 2000). "Identification and functional analysis of human Tom22 for protein import into mitochondria". Mol Cell Biol. 20 (19): 7205–13. doi:10.1128/MCB.20.19.7205-7213.2000. PMC 86274. PMID 10982837.

[pmid10900208-6] Saeki K, Suzuki H, Tsuneoka M, Maeda M, Iwamoto R, Hasuwa H, Shida S, Takahashi T, Sakaguchi M, Endo T, Miura Y, Mekada E, Mihara K (Nov 2000). "Identification of mammalian TOM22 as a subunit of the preprotein translocase of the mitochondrial outer membrane". J Biol Chem. 275 (41): 31996–2002. doi:10.1074/jbc.M004794200. PMID 10900208.

[entrez-7] "Entrez Gene: TOMM22 translocase of outer mitochondrial membrane 22 homolog (yeast)".

TOMM22

See also

References

Further reading