SMARCA5

SMARCA5
Identifiers
Aliases	SMARCA5, ISWI, SNF2H, WCRF135, hISWI, hSNF2H, SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5
External IDs	OMIM: 603375 MGI: 1935129 HomoloGene: 55764 GeneCards: SMARCA5
Gene location (Human)
Chr.	Chromosome 4 (human)
End	143,557,486 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	81,466,126 bp
RNA expression pattern
	Top expressed in
	Achilles tendon; ; ganglionic eminence; ; corpus callosum; ; superior vestibular nucleus; ; subthalamic nucleus; ; inferior ganglion of vagus nerve; ; internal globus pallidus; ; stromal cell of endometrium; ; oocyte; ; corpus epididymis;
	Top expressed in
	abdominal wall; ; maxillary prominence; ; cumulus cell; ; superior cervical ganglion; ; spermatocyte; ; somite; ; morula; ; ganglionic eminence; ; pineal gland; ; spermatid;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	nucleotide binding; helicase activity; histone binding; hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides; protein binding; nucleic acid binding; nucleosome binding; hydrolase activity; DNA binding; ATP binding; ATPase activity; DNA-binding transcription factor activity, RNA polymerase II-specific; ATP-dependent activity, acting on DNA;
Cellular component	RSF complex; nuclear replication fork; nucleoplasm; condensed chromosome; nucleus; fibrillar center; NURF complex; chromatin silencing complex; ISWI-type complex;
Biological process	epigenetic maintenance of chromatin in transcription-competent conformation; regulation of transcription by RNA polymerase II; CENP-A containing chromatin assembly; DNA-templated transcription, initiation; nucleosome assembly; chromatin remodeling; rDNA heterochromatin assembly; positive regulation of transcription, DNA-templated; cellular response to leukemia inhibitory factor; chromatin organization; positive regulation of transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologs
	8467
	93762
	ENSG00000153147
	ENSMUSG00000031715
	O60264
	Q91ZW3
	NM_003601
	NM_053124
	NP_003592
	NP_444354
	Wikidata
View/Edit Human	View/Edit Mouse

SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5 is a protein that in humans is encoded by the SMARCA5 gene.^[5]^[6]

Function

The protein encoded by this gene is a member of the ISWI family of proteins. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The protein encoded by this gene is a component of the chromatin remodeling and spacing factor RSF, a facilitator of the transcription of class II genes by RNA polymerase II. The encoded protein is similar in sequence to the Drosophila ISWI chromatin remodeling protein.^[6]

Interactions

SMARCA5 has been shown to interact with RAD21,^[7] Histone deacetylase 2,^[7] POLE3,^[8] SATB1^[9] and BAZ1A.^[7]^[8]^[9]^[10]^[11]

References

^ a b c GRCh38: Ensembl release 89: ENSG00000153147 – Ensembl, May 2017
^ a b c GRCm38: Ensembl release 89: ENSMUSG00000031715 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Aihara T, Miyoshi Y, Koyama K, Suzuki M, Takahashi E, Monden M, Nakamura Y (October 1998). "Cloning and mapping of SMARCA5 encoding hSNF2H, a novel human homologue of Drosophila ISWI". Cytogenetics and Cell Genetics. 81 (3–4): 191–3. doi:10.1159/000015027. PMID 9730600. S2CID 46768416.
^ a b "Entrez Gene: SMARCA5 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5".
^ a b c Hakimi MA, Bochar DA, Schmiesing JA, Dong Y, Barak OG, Speicher DW, Yokomori K, Shiekhattar R (Aug 2002). "A chromatin remodelling complex that loads cohesin onto human chromosomes". Nature. 418 (6901): 994–8. Bibcode:2002Natur.418..994H. doi:10.1038/nature01024. PMID 12198550. S2CID 4344470.
^ a b Poot RA, Dellaire G, Hülsmann BB, Grimaldi MA, Corona DF, Becker PB, Bickmore WA, Varga-Weisz PD (Jul 2000). "HuCHRAC, a human ISWI chromatin remodelling complex contains hACF1 and two novel histone-fold proteins". The EMBO Journal. 19 (13): 3377–87. doi:10.1093/emboj/19.13.3377. PMC 313940. PMID 10880450.
^ a b Yasui D, Miyano M, Cai S, Varga-Weisz P, Kohwi-Shigematsu T (Oct 2002). "SATB1 targets chromatin remodelling to regulate genes over long distances". Nature. 419 (6907): 641–5. Bibcode:2002Natur.419..641Y. doi:10.1038/nature01084. PMID 12374985. S2CID 25822700.
^ Bochar DA, Savard J, Wang W, Lafleur DW, Moore P, Côté J, Shiekhattar R (Feb 2000). "A family of chromatin remodeling factors related to Williams syndrome transcription factor". Proceedings of the National Academy of Sciences of the United States of America. 97 (3): 1038–43. Bibcode:2000PNAS...97.1038B. doi:10.1073/pnas.97.3.1038. PMC 15513. PMID 10655480.
^ Bozhenok L, Wade PA, Varga-Weisz P (May 2002). "WSTF-ISWI chromatin remodeling complex targets heterochromatic replication foci". The EMBO Journal. 21 (9): 2231–41. doi:10.1093/emboj/21.9.2231. PMC 125993. PMID 11980720.

Dirscherl SS, Krebs JE (Aug 2004). "Functional diversity of ISWI complexes". Biochemistry and Cell Biology. 82 (4): 482–9. doi:10.1139/o04-044. PMID 15284901.
LeRoy G, Orphanides G, Lane WS, Reinberg D (Dec 1998). "Requirement of RSF and FACT for transcription of chromatin templates in vitro". Science. 282 (5395): 1900–4. doi:10.1126/science.282.5395.1900. PMID 9836642.
Bochar DA, Savard J, Wang W, Lafleur DW, Moore P, Côté J, Shiekhattar R (Feb 2000). "A family of chromatin remodeling factors related to Williams syndrome transcription factor". Proceedings of the National Academy of Sciences of the United States of America. 97 (3): 1038–43. Bibcode:2000PNAS...97.1038B. doi:10.1073/pnas.97.3.1038. PMC 15513. PMID 10655480.
Poot RA, Dellaire G, Hülsmann BB, Grimaldi MA, Corona DF, Becker PB, Bickmore WA, Varga-Weisz PD (Jul 2000). "HuCHRAC, a human ISWI chromatin remodelling complex contains hACF1 and two novel histone-fold proteins". The EMBO Journal. 19 (13): 3377–87. doi:10.1093/emboj/19.13.3377. PMC 313940. PMID 10880450.
Stopka T, Zakova D, Fuchs O, Kubrova O, Blafkova J, Jelinek J, Necas E, Zivny J (Jul 2000). "Chromatin remodeling gene SMARCA5 is dysregulated in primitive hematopoietic cells of acute leukemia". Leukemia. 14 (7): 1247–52. doi:10.1038/sj.leu.2401807. PMID 10914549. S2CID 7991196.
Aalfs JD, Narlikar GJ, Kingston RE (Sep 2001). "Functional differences between the human ATP-dependent nucleosome remodeling proteins BRG1 and SNF2H". The Journal of Biological Chemistry. 276 (36): 34270–8. doi:10.1074/jbc.M104163200. PMID 11435432.
Strohner R, Nemeth A, Jansa P, Hofmann-Rohrer U, Santoro R, Längst G, Grummt I (Sep 2001). "NoRC--a novel member of mammalian ISWI-containing chromatin remodeling machines". The EMBO Journal. 20 (17): 4892–900. doi:10.1093/emboj/20.17.4892. PMC 125270. PMID 11532953.
Bozhenok L, Wade PA, Varga-Weisz P (May 2002). "WSTF-ISWI chromatin remodeling complex targets heterochromatic replication foci". The EMBO Journal. 21 (9): 2231–41. doi:10.1093/emboj/21.9.2231. PMC 125993. PMID 11980720.
Levine SS, Weiss A, Erdjument-Bromage H, Shao Z, Tempst P, Kingston RE (Sep 2002). "The core of the polycomb repressive complex is compositionally and functionally conserved in flies and humans". Molecular and Cellular Biology. 22 (17): 6070–8. doi:10.1128/MCB.22.17.6070-6078.2002. PMC 134016. PMID 12167701.
Hakimi MA, Bochar DA, Schmiesing JA, Dong Y, Barak OG, Speicher DW, Yokomori K, Shiekhattar R (Aug 2002). "A chromatin remodelling complex that loads cohesin onto human chromosomes". Nature. 418 (6901): 994–8. Bibcode:2002Natur.418..994H. doi:10.1038/nature01024. PMID 12198550. S2CID 4344470.
Yasui D, Miyano M, Cai S, Varga-Weisz P, Kohwi-Shigematsu T (Oct 2002). "SATB1 targets chromatin remodelling to regulate genes over long distances". Nature. 419 (6907): 641–5. Bibcode:2002Natur.419..641Y. doi:10.1038/nature01084. PMID 12374985. S2CID 25822700.
Collins N, Poot RA, Kukimoto I, García-Jiménez C, Dellaire G, Varga-Weisz PD (Dec 2002). "An ACF1-ISWI chromatin-remodeling complex is required for DNA replication through heterochromatin". Nature Genetics. 32 (4): 627–32. doi:10.1038/ng1046. PMID 12434153. S2CID 22545162.
Loyola A, Huang JY, LeRoy G, Hu S, Wang YH, Donnelly RJ, Lane WS, Lee SC, Reinberg D (Oct 2003). "Functional analysis of the subunits of the chromatin assembly factor RSF". Molecular and Cellular Biology. 23 (19): 6759–68. doi:10.1128/MCB.23.19.6759-6768.2003. PMC 193931. PMID 12972596.
Shu H, Chen S, Bi Q, Mumby M, Brekken DL (Mar 2004). "Identification of phosphoproteins and their phosphorylation sites in the WEHI-231 B lymphoma cell line". Molecular & Cellular Proteomics. 3 (3): 279–86. doi:10.1074/mcp.D300003-MCP200. PMID 14729942.
Obuse C, Yang H, Nozaki N, Goto S, Okazaki T, Yoda K (Feb 2004). "Proteomics analysis of the centromere complex from HeLa interphase cells: UV-damaged DNA binding protein 1 (DDB-1) is a component of the CEN-complex, while BMI-1 is transiently co-localized with the centromeric region in interphase". Genes to Cells. 9 (2): 105–20. doi:10.1111/j.1365-2443.2004.00705.x. PMID 15009096. S2CID 21813024.
Geiman TM, Sankpal UT, Robertson AK, Zhao Y, Zhao Y, Robertson KD (May 2004). "DNMT3B interacts with hSNF2H chromatin remodeling enzyme, HDACs 1 and 2, and components of the histone methylation system". Biochemical and Biophysical Research Communications. 318 (2): 544–55. doi:10.1016/j.bbrc.2004.04.058. PMID 15120635.
Geiman TM, Sankpal UT, Robertson AK, Chen Y, Mazumdar M, Heale JT, Schmiesing JA, Kim W, Yokomori K, Zhao Y, Robertson KD (2004). "Isolation and characterization of a novel DNA methyltransferase complex linking DNMT3B with components of the mitotic chromosome condensation machinery". Nucleic Acids Research. 32 (9): 2716–29. doi:10.1093/nar/gkh589. PMC 419596. PMID 15148359.

This article on a gene on human chromosome 4 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000153147 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000031715 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9730600-5] Aihara T, Miyoshi Y, Koyama K, Suzuki M, Takahashi E, Monden M, Nakamura Y (October 1998). "Cloning and mapping of SMARCA5 encoding hSNF2H, a novel human homologue of Drosophila ISWI". Cytogenetics and Cell Genetics. 81 (3–4): 191–3. doi:10.1159/000015027. PMID 9730600. S2CID 46768416.

[entrez-6] "Entrez Gene: SMARCA5 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5".

[pmid12198550-7] Hakimi MA, Bochar DA, Schmiesing JA, Dong Y, Barak OG, Speicher DW, Yokomori K, Shiekhattar R (Aug 2002). "A chromatin remodelling complex that loads cohesin onto human chromosomes". Nature. 418 (6901): 994–8. Bibcode:2002Natur.418..994H. doi:10.1038/nature01024. PMID 12198550. S2CID 4344470.

[pmid10880450-8] Poot RA, Dellaire G, Hülsmann BB, Grimaldi MA, Corona DF, Becker PB, Bickmore WA, Varga-Weisz PD (Jul 2000). "HuCHRAC, a human ISWI chromatin remodelling complex contains hACF1 and two novel histone-fold proteins". The EMBO Journal. 19 (13): 3377–87. doi:10.1093/emboj/19.13.3377. PMC 313940. PMID 10880450.

[pmid12374985-9] Yasui D, Miyano M, Cai S, Varga-Weisz P, Kohwi-Shigematsu T (Oct 2002). "SATB1 targets chromatin remodelling to regulate genes over long distances". Nature. 419 (6907): 641–5. Bibcode:2002Natur.419..641Y. doi:10.1038/nature01084. PMID 12374985. S2CID 25822700.

[pmid10655480-10] Bochar DA, Savard J, Wang W, Lafleur DW, Moore P, Côté J, Shiekhattar R (Feb 2000). "A family of chromatin remodeling factors related to Williams syndrome transcription factor". Proceedings of the National Academy of Sciences of the United States of America. 97 (3): 1038–43. Bibcode:2000PNAS...97.1038B. doi:10.1073/pnas.97.3.1038. PMC 15513. PMID 10655480.

[pmid11980720-11] Bozhenok L, Wade PA, Varga-Weisz P (May 2002). "WSTF-ISWI chromatin remodeling complex targets heterochromatic replication foci". The EMBO Journal. 21 (9): 2231–41. doi:10.1093/emboj/21.9.2231. PMC 125993. PMID 11980720.

SMARCA5

Function

Interactions

References

Further reading