PAFAH1B3

PAFAH1B3
Identifiers
Aliases	PAFAH1B3, PAFAHG, platelet activating factor acetylhydrolase 1b catalytic subunit 3
External IDs	OMIM: 603074; MGI: 108414; HomoloGene: 1933; GeneCards: PAFAH1B3; OMA:PAFAH1B3 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	42,303,546 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	24,997,411 bp
RNA expression pattern
	Top expressed in
	ganglionic eminence; ; ventricular zone; ; gonad; ; right hemisphere of cerebellum; ; mucosa of transverse colon; ; nucleus accumbens; ; testicle; ; prefrontal cortex; ; right adrenal gland; ; amygdala;
	Top expressed in
	medial ganglionic eminence; ; neural tube; ; ventricular zone; ; maxillary prominence; ; mandibular prominence; ; human fetus; ; efferent ductule; ; hand; ; abdominal wall; ; migratory enteric neural crest cell;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	1-alkyl-2-acetylglycerophosphocholine esterase activity; platelet-activating factor acetyltransferase activity; protein binding; hydrolase activity; identical protein binding; protein heterodimerization activity; phospholipase A2 activity;
Cellular component	cytoplasm; extracellular exosome; membrane; cytosol;
Biological process	lipid catabolic process; brain development; spermatogenesis; nervous system development; lipid metabolism;
	Sources:Amigo / QuickGO
Orthologs
	5050
	18476
	ENSG00000079462
	ENSMUSG00000005447
	Q15102
	Q61205
	NM_002573; NM_001145939; NM_001145940
	NM_008776; NM_001357350
	NP_001139411; NP_001139412; NP_002564
	NP_032802; NP_001344279
	Wikidata
View/Edit Human	View/Edit Mouse

Platelet-activating factor acetylhydrolase IB subunit gamma is an enzyme that in humans is encoded by the PAFAH1B3 gene.^[5]^[6]

Interactions

PAFAH1B3 has been shown to interact with PAFAH1B1^[7] and LNX1.^[8]

References

^ a b c GRCh38: Ensembl release 89: ENSG00000079462 – Ensembl, May 2017
^ a b c GRCm38: Ensembl release 89: ENSMUSG00000005447 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Adachi H, Tsujimoto M, Hattori M, Arai H, Inoue K (Sep 1995). "cDNA cloning of human cytosolic platelet-activating factor acetylhydrolase gamma-subunit and its mRNA expression in human tissues". Biochemical and Biophysical Research Communications. 214 (1): 180–7. doi:10.1006/bbrc.1995.2272. PMID 7669037.
^ "Entrez Gene: PAFAH1B3 platelet-activating factor acetylhydrolase, isoform Ib, gamma subunit 29kDa".
^ Sweeney KJ, Clark GD, Prokscha A, Dobyns WB, Eichele G (Apr 2000). "Lissencephaly associated mutations suggest a requirement for the PAFAH1B heterotrimeric complex in brain development". Mechanisms of Development. 92 (2): 263–71. doi:10.1016/S0925-4773(00)00242-2. PMID 10727864. S2CID 2447495.
^ Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.

Moro F, Arrigo G, Fogli A, Bernard L, Carrozzo R (Jul 1998). "The beta and gamma subunits of the human platelet-activating factor acetyl hydrolase isoform Ib (PAFAH1B2 and PAFAH1B3) map to chromosome 11q23 and 19q13.1, respectively". Genomics. 51 (1): 157–9. doi:10.1006/geno.1998.5322. PMID 9693049.
Sweeney KJ, Clark GD, Prokscha A, Dobyns WB, Eichele G (Apr 2000). "Lissencephaly associated mutations suggest a requirement for the PAFAH1B heterotrimeric complex in brain development". Mechanisms of Development. 92 (2): 263–71. doi:10.1016/S0925-4773(00)00242-2. PMID 10727864. S2CID 2447495.
Sheffield PJ, McMullen TW, Li J, Ho YS, Garrard SM, Derewenda U, Derewenda ZS (Jul 2001). "Preparation and crystal structure of the recombinant alpha(1)/alpha(2) catalytic heterodimer of bovine brain platelet-activating factor acetylhydrolase Ib". Protein Engineering. 14 (7): 513–9. doi:10.1093/protein/14.7.513. PMID 11522926.
Saito Y, Doi K, Yamagishi N, Ishihara K, Hatayama T (Feb 2004). "Screening of Hsp105alpha-binding proteins using yeast and bacterial two-hybrid systems". Biochemical and Biophysical Research Communications. 314 (2): 396–402. doi:10.1016/j.bbrc.2003.12.108. PMID 14733918.
Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE (Sep 2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. hdl:11858/00-001M-0000-0010-8592-0. PMID 16169070. S2CID 8235923.
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Guo D, Han J, Adam BL, Colburn NH, Wang MH, Dong Z, Eizirik DL, She JX, Wang CY (Dec 2005). "Proteomic analysis of SUMO4 substrates in HEK293 cells under serum starvation-induced stress". Biochemical and Biophysical Research Communications. 337 (4): 1308–18. doi:10.1016/j.bbrc.2005.09.191. PMID 16236267.

This article on a gene on human chromosome 19 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000079462 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000005447 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7669037-5] Adachi H, Tsujimoto M, Hattori M, Arai H, Inoue K (Sep 1995). "cDNA cloning of human cytosolic platelet-activating factor acetylhydrolase gamma-subunit and its mRNA expression in human tissues". Biochemical and Biophysical Research Communications. 214 (1): 180–7. doi:10.1006/bbrc.1995.2272. PMID 7669037.

[entrez-6] "Entrez Gene: PAFAH1B3 platelet-activating factor acetylhydrolase, isoform Ib, gamma subunit 29kDa".

[pmid10727864-7] Sweeney KJ, Clark GD, Prokscha A, Dobyns WB, Eichele G (Apr 2000). "Lissencephaly associated mutations suggest a requirement for the PAFAH1B heterotrimeric complex in brain development". Mechanisms of Development. 92 (2): 263–71. doi:10.1016/S0925-4773(00)00242-2. PMID 10727864. S2CID 2447495.

[pmid16189514-8] Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.

PAFAH1B3

Interactions

See also

References

Further reading