OEA is a shorter, monounsaturated analogue of the endocannabinoidanandamide, but unlike anandamide it acts independently of the cannabinoid pathway, regulating PPAR-α activity to stimulate lipolysis.[4]
OEA has been demonstrated to bind to the novel cannabinoid receptorGPR119.[7] OEA has been suggested to be the receptor's endogenous ligand.[8]
OEA has been hypothesized to play a key role in the inhibition of food seeking behavior and in the lipolysis of brown bears "ursus arctos" during the hibernation season together with the alteration of the endocannabinoid system required for the metabolic changes for hibernation.[9]
OEA has been reported to lengthen the life span of the roundworm Caenorhabditis elegans through interactions with lysomal molecules.[10]
References
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^Lo Verme J, Gaetani S, Fu J, Oveisi F, Burton K, Piomelli D (2005). "Regulation of food intake by oleoylethanolamine". Cell. Mol. Life Sci. 62 (6): 708–16. doi:10.1007/s00018-004-4494-0. PMID 15770421. S2CID 26838764.
^Giuseppe Astarita; Bryan C. Rourke; Johnnie B. Andersen; Jin Fu; Janet H. Kim; Albert F. Bennett; James W. Hicks & Daniele Piomelli (2005-12-22). "Postprandial increase of oleoylethanolamine mobilization in small intestine of the Burmese python (Python molurus)". Am J Physiol Regul Integr Comp Physiol. 290 (5): R1407–R1412. doi:10.1152/ajpregu.00664.2005. PMID 16373434. S2CID 11852711.
^Gaetani S, Kaye WH, Cuomo V, Piomelli D (September 2008). "Role of endocannabinoids and their analogues in obesity and eating disorders". Eat Weight Disord. 13 (3): e42–8. PMID 19011363.
^illustration
^Magotti P, Bauer I, Igarashi M, Babagoli M, Marotta R, Piomelli D, Garau G (Dec 2014). "Structure of Human N-Acylphosphatidylethanolamine-Hydrolyzing Phospholipase D: Regulation of Fatty Acid Ethanolamide Biosynthesis by Bile Acids". Structure. 23 (3): 598–604. doi:10.1016/j.str.2014.12.018. PMC4351732. PMID 25684574.
^Overton HA, Babbs AJ, Doel SM, Fyfe MC, Gardner LS, Griffin G, Jackson HC, Procter MJ, Rasamison CM, Tang-Christensen M, Widdowson PS, Williams GM, Reynet C (2006). "Deorphanization of a G protein-coupled receptor for oleoylethanolamide and its use in the discovery of small-molecule hypophagic agents". Cell Metab. 3 (3): 167–175. doi:10.1016/j.cmet.2006.02.004. PMID 16517404.
^Boyer C, Cussonneau L, Brun C, Deval C, Pais de Barros JP, Chanon S, Bernoud-Hubac N, Daira P, Evans AL, Arnemo JM, Swenson JE, Gauquelin-Koch G, Simon C, Blanc S, Combaret L, Bertile F, Lefai E (2020). "Specific shifts in the endocannabinoid system in hibernating brown bears". Frontiers in Zoology. 17 (1): 35. doi:10.1186/s12983-020-00380-y. PMC7681968. PMID 33292302.
^Folick A, Oakley HD, Yu Y, Armstrong EH, Kumari M, Sanor L, Moore DD, Ortlund EA, Zechner R, Wang MC (2015). "Aging. Lysosomal signaling molecules regulate longevity in Caenorhabditis elegans". Science. 347 (6217): 83–6. doi:10.1126/science.1258857. PMC4425353. PMID 25554789.