Ninein

NIN
Identifiers
Aliases	NIN, SCKL7, ninein
External IDs	OMIM: 608684 MGI: 105108 HomoloGene: 40632 GeneCards: NIN
Gene location (Human)
Chr.	Chromosome 14 (human)
End	50,831,162 bp
Gene location (Mouse)
Chr.	Chromosome 12 (mouse)
End	70,160,491 bp
RNA expression pattern
	Top expressed in
	bone marrow cells; ; blood; ; sural nerve; ; monocyte; ; trabecular bone; ; internal globus pallidus; ; corpus callosum; ; lymph node; ; superficial temporal artery; ; placenta;
	Top expressed in
	secondary oocyte; ; olfactory epithelium; ; morula; ; blood; ; olfactory tubercle; ; pineal gland; ; medial dorsal nucleus; ; subiculum; ; renal corpuscle; ; lateral geniculate nucleus;
	More reference expression data
	n/a
Gene ontology
Molecular function	nucleotide binding; calcium ion binding; GTP binding; protein binding; kinase binding;
Cellular component	cytoplasm; microtubule organizing center; spindle pole; nucleolus; pericentriolar material; microtubule; cytoskeleton; mitotic spindle pole; microtubule minus-end; centrosome; ciliary transition fiber; nucleus; centriole; mitotic spindle; centriolar subdistal appendage; plasma membrane; axon; dendrite; axonal growth cone; apical part of cell;
Biological process	centrosome localization; centrosome-templated microtubule nucleation; microtubule anchoring at centrosome; protein localization; centriole-centriole cohesion; corpus callosum morphogenesis; corticospinal tract morphogenesis; positive regulation of microtubule polymerization; collateral sprouting; positive regulation of axonogenesis;
	Sources:Amigo / QuickGO
Orthologs
	51199
	18080
	ENSG00000100503
	ENSMUSG00000021068
	Q8N4C6
	Q61043
	NM_016350; NM_020921; NM_182944; NM_182945; NM_182946
	NM_001081453; NM_001286079; NM_001286080; NM_008697
	NP_057434; NP_065972; NP_891989; NP_891991
	NP_001074922; NP_001273008; NP_001273009; NP_032723; NP_001390761
	Wikidata
View/Edit Human	View/Edit Mouse

Ninein is a protein that in humans is encoded by the NIN gene.^[5]^[6]^[7]

Function

Ninein, together with its paralog Ninein-like protein is one of the proteins important for centrosomal function. Localization of this protein to the centrosome requires three leucine zippers in the central coiled-coil domain. Multiple alternatively spliced transcript variants that encode different isoforms have been reported.^[7]

This protein is important for positioning and anchoring the microtubules minus-ends in epithelial cells.^[7]

References

^ a b c GRCh38: Ensembl release 89: ENSG00000100503 – Ensembl, May 2017
^ a b c GRCm38: Ensembl release 89: ENSMUSG00000021068 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Hong YR, Chen CH, Chang JH, Wang S, Sy WD, Chou CK, Howng SL (Oct 2000). "Cloning and characterization of a novel human ninein protein that interacts with the glycogen synthase kinase 3beta". Biochim Biophys Acta. 1492 (2–3): 513–6. doi:10.1016/S0167-4781(00)00127-5. PMID 11004522.
^ Hong YR, Chen CH, Chuo MH, Liou SY, Howng SL (Feb 2001). "Genomic organization and molecular characterization of the human ninein gene". Biochem. Biophys. Res. Commun. 279 (3): 989–95. doi:10.1006/bbrc.2000.4050. PMID 11162463.
^ a b c "Entrez Gene: NIN ninein (GSK3B interacting protein)".

Nakajima D, Okazaki N, Yamakawa H, et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Res. 9 (3): 99–106. doi:10.1093/dnares/9.3.99. PMID 12168954.
Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
Mack GJ, Rees J, Sandblom O, et al. (1998). "Autoantibodies to a group of centrosomal proteins in human autoimmune sera reactive with the centrosome". Arthritis Rheum. 41 (3): 551–8. doi:10.1002/1529-0131(199803)41:3<551::AID-ART22>3.0.CO;2-X. PMID 9506584.
Nagase T, Kikuno R, Nakayama M, et al. (2001). "Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (4): 273–81. doi:10.1093/dnares/7.4.271. PMID 10997877.
Ou YY, Mack GJ, Zhang M, Rattner JB (2002). "CEP110 and ninein are located in a specific domain of the centrosome associated with centrosome maturation". J. Cell Sci. 115 (Pt 9): 1825–35. doi:10.1242/jcs.115.9.1825. PMID 11956314.
Dammermann A, Merdes A (2002). "Assembly of centrosomal proteins and microtubule organization depends on PCM-1". J. Cell Biol. 159 (2): 255–66. doi:10.1083/jcb.200204023. PMC 2173044. PMID 12403812.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Chen CH, Howng SL, Cheng TS, et al. (2003). "Molecular characterization of human ninein protein: two distinct subdomains required for centrosomal targeting and regulating signals in cell cycle". Biochem. Biophys. Res. Commun. 308 (4): 975–83. doi:10.1016/S0006-291X(03)01510-9. PMID 12927815.
Fritzler MJ, Zhang M, Stinton LM, Rattner JB (2004). "Spectrum of centrosome autoantibodies in childhood varicella and post-varicella acute cerebellar ataxia". BMC Pediatrics. 3: 11. doi:10.1186/1471-2431-3-11. PMC 222907. PMID 14503922.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Innocenti M, Zucconi A, Disanza A, et al. (2004). "Abi1 is essential for the formation and activation of a WAVE2 signalling complex". Nat. Cell Biol. 6 (4): 319–27. doi:10.1038/ncb1105. PMID 15048123. S2CID 22767022.
Vizmanos JL, Novo FJ, Román JP, et al. (2004). "NIN, a gene encoding a CEP110-like centrosomal protein, is fused to PDGFRB in a patient with a t(5;14)(q33;q24) and an imatinib-responsive myeloproliferative disorder". Cancer Res. 64 (8): 2673–6. doi:10.1158/0008-5472.CAN-04-0144. PMID 15087377.
Howng SL, Hsu HC, Cheng TS, et al. (2004). "A novel ninein-interaction protein, CGI-99, blocks ninein phosphorylation by GSK3beta and is highly expressed in brain tumors". FEBS Lett. 566 (1–3): 162–8. doi:10.1016/j.febslet.2004.04.024. PMID 15147888.
Stillwell EE, Zhou J, Joshi HC (2006). "Human ninein is a centrosomal autoantigen recognized by CREST patient sera and plays a regulatory role in microtubule nucleation". Cell Cycle. 3 (7): 923–30. doi:10.4161/cc.3.7.947. PMID 15190203.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Delgehyr N, Sillibourne J, Bornens M (2005). "Microtubule nucleation and anchoring at the centrosome are independent processes linked by ninein function". J. Cell Sci. 118 (Pt 8): 1565–75. doi:10.1242/jcs.02302. PMID 15784680.
Cheng TS, Chang LK, Howng SL, et al. (2006). "SUMO-1 modification of centrosomal protein hNinein promotes hNinein nuclear localization". Life Sci. 78 (10): 1114–20. doi:10.1016/j.lfs.2005.06.021. PMID 16154161.

This article on a gene on human chromosome 14 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000100503 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000021068 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11004522-5] Hong YR, Chen CH, Chang JH, Wang S, Sy WD, Chou CK, Howng SL (Oct 2000). "Cloning and characterization of a novel human ninein protein that interacts with the glycogen synthase kinase 3beta". Biochim Biophys Acta. 1492 (2–3): 513–6. doi:10.1016/S0167-4781(00)00127-5. PMID 11004522.

[pmid11162463-6] Hong YR, Chen CH, Chuo MH, Liou SY, Howng SL (Feb 2001). "Genomic organization and molecular characterization of the human ninein gene". Biochem. Biophys. Res. Commun. 279 (3): 989–95. doi:10.1006/bbrc.2000.4050. PMID 11162463.

[entrez-7] "Entrez Gene: NIN ninein (GSK3B interacting protein)".

v t e The centrosome and its components
Centrioles	SASS6 CENPJ CNTROB CEP104 Centrins (CETN1, CETN2 and CETN3) SFI1
Pericentriolar material	BBS4 Lck PCM1 PCNT TNKS TNKS2 TUBE1
other proteins	CCP110 CEP55 CEP57 CEP63 CEP68 CEP70 CEP72 CEP76 CEP78 CEP90 CEP97 CEP120 CEP135 CEP152 CEP164 CEP170 CEP192 CEP215 CEP250 CEP350 CNTRL NIN NINL

Ninein

Function

References

Further reading