In August 2019, he was named in the startlist for the 2019 Vuelta a España. In 2021 he entered his second edition of the Vuelta, his first riding for Team Jumbo-Visma. He rode in support of Primož Roglič, who won the race. He was named to the team for the 2022 Tour de France and ended up playing an important role. Between Roglič, Vingegaard and van Aert fighting for stage wins, jerseys and the Tour de France itself, Van Hooydonck was one of the domestiques doing whatever was asked of him for the team. He had to leave the race just two stages before the end, due to a personal matter beyond his control.
^"2019: 74th La Vuelta ciclista a España". ProCyclingStats. Retrieved 23 August 2019.
^McGrath, Andy (23 July 2022). "Nathan Van Hooydonck abandons Tour de France before stage 20 due to 'family circumstances': Jumbo-Visma domestique's departure leaves team of race leader Jonas Vingegaard down to five riders". Velo News by Outside Magazine. Retrieved 29 July 2022.
Wikimedia Commons has media related to Nathan Van Hooydonck.