MYBPC1

MYBPC1
Available structures
PDB	Human UniProt search: PDBe RCSB
List of PDB id codes
	1X44, 2DAV, 2YUV, 2YUW, 2YUX, 2YUZ, 2YXM
Identifiers
Aliases	MYBPC1, LCCS4, MYBPCC, MYBPCS, myosin binding protein C, slow type, ssMyBP-C, MYOTREM, myosin binding protein C1
External IDs	OMIM: 160794 MGI: 1336213 HomoloGene: 1846 GeneCards: MYBPC1
Gene location (Human)
Chr.	Chromosome 12 (human)
End	101,686,028 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	88,441,014 bp
RNA expression pattern
	Top expressed in
	biceps brachii; ; deltoid muscle; ; gastrocnemius muscle; ; vastus lateralis muscle; ; triceps brachii muscle; ; thoracic diaphragm; ; tibialis anterior muscle; ; body of tongue; ; optic nerve; ; internal globus pallidus;
	Top expressed in
	temporal muscle; ; ankle; ; soleus muscle; ; sternocleidomastoid muscle; ; digastric muscle; ; tibialis anterior muscle; ; extraocular muscle; ; thoracic diaphragm; ; vastus lateralis muscle; ; gastrocnemius muscle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	actin binding; structural constituent of muscle; protein binding; titin binding; actin filament binding; muscle alpha-actinin binding; structural molecule activity conferring elasticity;
Cellular component	myosin filament; cytosol; myofibril; muscle myosin complex; Z disc; M band; striated muscle thin filament; sarcomere;
Biological process	cell adhesion; muscle contraction; muscle filament sliding; striated muscle contraction; actin filament organization; sarcomere organization; striated muscle myosin thick filament assembly; skeletal muscle thin filament assembly; skeletal muscle myosin thick filament assembly; cardiac myofibril assembly; cardiac muscle tissue morphogenesis;
	Sources:Amigo / QuickGO
Orthologs
	4604
	109272
	ENSG00000196091
	ENSMUSG00000020061
	Q00872
	n/a
NM_001254718; NM_001254719; NM_001254720; NM_001254721; NM_001254722;
	NM_001254723; NM_002465; NM_206819; NM_206820; NM_206821; NM_001404675; NM_001404676; NM_001404677; NM_001404678; NM_001404679; NM_001404680; NM_001404681
	NM_001252372; NM_175418
NP_001241647; NP_001241648; NP_001241649; NP_001241650; NP_001241651;
	NP_001241652; NP_002456; NP_996555; NP_996556; NP_996557
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Myosin-binding protein C, slow-type is a protein that in humans is encoded by the MYBPC1 gene.^[5]^[6]^[7]

References

^ a b c GRCh38: Ensembl release 89: ENSG00000196091 – Ensembl, May 2017
^ a b c GRCm38: Ensembl release 89: ENSMUSG00000020061 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Weber FE, Vaughan KT, Reinach FC, Fischman DA (Oct 1993). "Complete sequence of human fast-type and slow-type muscle myosin-binding-protein C (MyBP-C). Differential expression, conserved domain structure and chromosome assignment". Eur J Biochem. 216 (2): 661–9. doi:10.1111/j.1432-1033.1993.tb18186.x. PMID 8375400.
^ Flashman E, Watkins H, Redwood C (Dec 2006). "Localization of the binding site of the C-terminal domain of cardiac myosin-binding protein-C on the myosin rod". Biochem J. 401 (1): 97–102. doi:10.1042/BJ20060500. PMC 1698665. PMID 16918501.
^ "Entrez Gene: MYBPC1 myosin binding protein C, slow type".

Fürst DO, Vinkemeier U, Weber K (1992). "Mammalian skeletal muscle C-protein: purification from bovine muscle, binding to titin and the characterization of a full-length human cDNA". J. Cell Sci. 102 (4): 769–78. doi:10.1242/jcs.102.4.769. PMID 1429890.
Johnston LH, Barker DG, Nurse P (1986). "Cloning and characterization of the Schizosaccharomyces pombe DNA ligase gene CDC17". Gene. 41 (2–3): 321–5. doi:10.1016/0378-1119(86)90114-9. PMID 3011605.
Auffray C, Behar G, Bois F, et al. (1995). "[IMAGE: molecular integration of the analysis of the human genome and its expression]". Comptes Rendus de l'Académie des Sciences, Série III. 318 (2): 263–72. PMID 7757816.
Hillier LD, Lennon G, Becker M, et al. (1997). "Generation and analysis of 280,000 human expressed sequence tags". Genome Res. 6 (9): 807–28. doi:10.1101/gr.6.9.807. PMID 8889549.
Alyonycheva TN, Mikawa T, Reinach FC, Fischman DA (1997). "Isoform-specific interaction of the myosin-binding proteins (MyBPs) with skeletal and cardiac myosin is a property of the C-terminal immunoglobulin domain". J. Biol. Chem. 272 (33): 20866–72. doi:10.1074/jbc.272.33.20866. PMID 9252413.
Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
Welikson RE, Fischman DA (2003). "The C-terminal IgI domains of myosin-binding proteins C and H (MyBP-C and MyBP-H) are both necessary and sufficient for the intracellular crosslinking of sarcomeric myosin in transfected non-muscle cells". J. Cell Sci. 115 (Pt 17): 3517–26. doi:10.1242/jcs.115.17.3517. PMID 12154082.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Konno T, Shimizu M, Ino H, et al. (2003). "A novel missense mutation in the myosin binding protein-C gene is responsible for hypertrophic cardiomyopathy with left ventricular dysfunction and dilation in elderly patients". J. Am. Coll. Cardiol. 41 (5): 781–6. doi:10.1016/S0735-1097(02)02957-1. hdl:2297/15819. PMID 12628722.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Beatham J, Romero R, Townsend SK, et al. (2006). "Filamin C interacts with the muscular dystrophy KY protein and is abnormally distributed in mouse KY deficient muscle fibres". Hum. Mol. Genet. 13 (22): 2863–74. doi:10.1093/hmg/ddh308. PMID 15385448.
Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
Dhoot GK, Perry SV (2006). "Expression of slow skeletal myosin binding C-protein in normal adult mammalian heart". J. Muscle Res. Cell. Motil. 26 (2–3): 143–8. doi:10.1007/s10974-005-3089-1. PMID 16003462. S2CID 12278011.
Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
McGrath MJ, Cottle DL, Nguyen MA, et al. (2006). "Four and a half LIM protein 1 binds myosin-binding protein C and regulates myosin filament formation and sarcomere assembly". J. Biol. Chem. 281 (11): 7666–83. doi:10.1074/jbc.M512552200. PMID 16407297.

This article on a gene on human chromosome 12 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000196091 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000020061 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8375400-5] Weber FE, Vaughan KT, Reinach FC, Fischman DA (Oct 1993). "Complete sequence of human fast-type and slow-type muscle myosin-binding-protein C (MyBP-C). Differential expression, conserved domain structure and chromosome assignment". Eur J Biochem. 216 (2): 661–9. doi:10.1111/j.1432-1033.1993.tb18186.x. PMID 8375400.

[pmid16918501-6] Flashman E, Watkins H, Redwood C (Dec 2006). "Localization of the binding site of the C-terminal domain of cardiac myosin-binding protein-C on the myosin rod". Biochem J. 401 (1): 97–102. doi:10.1042/BJ20060500. PMC 1698665. PMID 16918501.

[entrez-7] "Entrez Gene: MYBPC1 myosin binding protein C, slow type".

MYBPC1

References

Further reading