Protein family
The leukotriene (LT ) receptors are G protein-coupled receptors that bind and are activated by the leukotrienes . They include the following proteins :
The recently elucidated CysLTE , represented by GPR99/OXGR1 , may constitute a third CysLTR.[1]
See also
References
^ Kanaoka Y, Maekawa A, Austen KF (2013). "Identification of GPR99 protein as a potential third cysteinyl leukotriene receptor with a preference for leukotriene E4 ligand". J. Biol. Chem . 288 (16): 10967–72. doi :10.1074/jbc.C113.453704 . PMC 3630866 . PMID 23504326.
External links
IUPHAR GPCR Database – Leukotriene receptors
Leukotriene+Receptors at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
Receptor (ligands )
BLT Tooltip Leukotriene B4 receptor
BLT1 Tooltip Leukotriene B4 receptor 1
Antagonists: 20-Carboxy-LTB4
Amelubant
CGS-23131 (LY-223982)
CGS-25019C
CP-105696
CP-195543
Etalocib
LY-293111
Moxilubant
ONO-4057
RG-14893
RP-69698
SB-209247
SC-53228
Ticolubant
U-75302
ZK-158252
BLT2 Tooltip Leukotriene B4 receptor 2
Antagonists: CP-195543
LY-255283
ZK-158252
CysLT Tooltip Cysteinyl leukotriene receptor
CysLT1 Tooltip Cysteinyl leukotriene receptor 1
Antagonists: Ablukast
BAYu9773
BAYu9916
BAYx7195
Cinalukast
FPL-55712
ICI-198615
Iralukast
LY-170680
Masilukast
MK-571
Montelukast
ONO-1078
Pobilukast
Pranlukast
Ritolukast
SKF-104353
SR-2640
Sulukast
Tipelukast
Tomelukast
Verlukast
Zafirlukast
ZD-3523
CysLT2 Tooltip Cysteinyl leukotriene receptor 2
Antagonists: BAYu9773
BAYu9916
CysLTE Tooltip Cysteinyl leukotriene receptor E
Enzyme (inhibitors )
5-LOX Tooltip Arachidonate 5-lipoxygenase
FLAP Tooltip Arachidonate 5-lipoxygenase-activating protein inhibitors: AM-103
AM-679
BAYx1005
MK-591
MK-886
12-LOX Tooltip Arachidonate 12-lipoxygenase 15-LOX Tooltip Arachidonate 15-lipoxygenase LTA4 H Tooltip Leukotriene A4 hydrolase LTB4 H Tooltip Leukotriene B4 ω-hydroxylase LTC4 S Tooltip Leukotriene C4 synthase LTC4 H Tooltip Leukotriene C4 hydrolase LTD4 Tooltip Leukotriene D4 hydrolase
Others