Leiomodin 1

LMOD1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4Z79, 4Z8G, 4Z94
Identifiers
Aliases	LMOD1, 1D, 64kD, D1, SM-LMOD, SMLMOD, leiomodin 1, MMIHS3
External IDs	OMIM: 602715 MGI: 2135671 HomoloGene: 8118 GeneCards: LMOD1
Gene location (Human)
Chr.	Chromosome 1 (human)
End	201,946,588 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	135,295,803 bp
RNA expression pattern
	Top expressed in
	popliteal artery; ; right coronary artery; ; gastric mucosa; ; ascending aorta; ; saphenous vein; ; left coronary artery; ; left uterine tube; ; myometrium; ; urethra; ; canal of the cervix;
	Top expressed in
	ascending aorta; ; aortic valve; ; interventricular septum; ; esophagus; ; urinary bladder; ; uterus; ; left colon; ; duodenum; ; internal carotid artery; ; external carotid artery;
	More reference expression data
	n/a
Gene ontology
Molecular function	actin binding; tropomyosin binding;
Cellular component	cytoskeleton; membrane; sarcomere; myofibril; cytoplasm; cytosol; actin filament; striated muscle thin filament;
Biological process	pointed-end actin filament capping; actin nucleation; positive regulation of actin filament polymerization; muscle contraction; myofibril assembly;
	Sources:Amigo / QuickGO
Orthologs
	25802
	93689
	ENSG00000163431
	ENSMUSG00000048096
	P29536
	Q8BVA4
	NM_012134
	NM_053106
	NP_036266
	NP_444336
	Wikidata
View/Edit Human	View/Edit Mouse

Leiomodin 1 is a protein that in humans is encoded by the LMOD1 gene. ^[5]

Function

The leiomodin 1 protein has a putative membrane-spanning region and 2 types of tandemly repeated blocks. The transcript is expressed in all tissues tested, with the highest levels in thyroid, eye muscle, skeletal muscle, and ovary. Increased expression of leiomodin 1 may be linked to Graves' disease and thyroid-associated ophthalmopathy. [provided by RefSeq, Jul 2008].

References

^ a b c GRCh38: Ensembl release 89: ENSG00000163431 – Ensembl, May 2017
^ a b c GRCm38: Ensembl release 89: ENSMUSG00000048096 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: Leiomodin 1". Retrieved 2018-03-12.

Conley CA, Fowler VM (October 1999). "Localization of the human 64kD autoantigen D1 to myofibrils in a subset of extraocular muscle fibers". Curr. Eye Res. 19 (4): 313–22. doi:10.1076/ceyr.19.4.313.5304. PMID 10520227.
Conley CA, Fritz-Six KL, Almenar-Queralt A, Fowler VM (April 2001). "Leiomodins: larger members of the tropomodulin (Tmod) gene family". Genomics. 73 (2): 127–39. doi:10.1006/geno.2000.6501. PMID 11318603.
Conley CA (June 2001). "Leiomodin and tropomodulin in smooth muscle". Am. J. Physiol., Cell Physiol. 280 (6): C1645–56. doi:10.1152/ajpcell.2001.280.6.C1645. PMID 11350761. S2CID 20779719.
Lane HY, Liu YC, Huang CL, Chang YC, Wu PL, Lu CT, Chang WH (April 2006). "Risperidone-related weight gain: genetic and nongenetic predictors". J Clin Psychopharmacol. 26 (2): 128–34. doi:10.1097/01.jcp.0000203196.65710.2b. PMID 16633140. S2CID 34821033.
Hosgood HD, Menashe I, Shen M, Yeager M, Yuenger J, Rajaraman P, He X, Chatterjee N, Caporaso NE, Zhu Y, Chanock SJ, Zheng T, Lan Q (October 2008). "Pathway-based evaluation of 380 candidate genes and lung cancer susceptibility suggests the importance of the cell cycle pathway". Carcinogenesis. 29 (10): 1938–43. doi:10.1093/carcin/bgn178. PMC 2722857. PMID 18676680.
Shen M, Vermeulen R, Rajaraman P, Menashe I, He X, Chapman RS, Yeager M, Thomas G, Burdett L, Hutchinson A, Yuenger J, Chanock S, Lan Q (May 2009). "Polymorphisms in innate immunity genes and lung cancer risk in Xuanwei, China". Environ. Mol. Mutagen. 50 (4): 285–90. Bibcode:2009EnvMM..50..285S. doi:10.1002/em.20452. PMC 2666781. PMID 19170196.
Hosgood HD, Menashe I, He X, Chanock S, Lan Q (December 2009). "PTEN identified as important risk factor of chronic obstructive pulmonary disease". Respir Med. 103 (12): 1866–70. doi:10.1016/j.rmed.2009.06.016. PMC 2783799. PMID 19625176.
Guey LT, García-Closas M, Murta-Nascimento C, Lloreta J, Palencia L, Kogevinas M, Rothman N, Vellalta G, Calle ML, Marenne G, Tardón A, Carrato A, García-Closas R, Serra C, Silverman DT, Chanock S, Real FX, Malats N (February 2010). "Genetic susceptibility to distinct bladder cancer subphenotypes". Eur. Urol. 57 (2): 283–92. doi:10.1016/j.eururo.2009.08.001. PMC 3220186. PMID 19692168.
Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD (November 2009). "Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip". Am. J. Hum. Genet. 85 (5): 628–42. doi:10.1016/j.ajhg.2009.10.014. PMC 2775832. PMID 19913121.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article on a gene on human chromosome 1 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000163431 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000048096 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: Leiomodin 1". Retrieved 2018-03-12.

Leiomodin 1

Function

References

Further reading