HOXD1

HOXD1
Identifiers
Aliases	HOXD1, HOX4, HOX4G, Hox-4.7, homeobox D1
External IDs	OMIM: 142987 MGI: 96201 HomoloGene: 7772 GeneCards: HOXD1
Gene location (Human)
Chr.	Chromosome 2 (human)
End	176,190,907 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	74,595,486 bp
RNA expression pattern
	Top expressed in
	corpus epididymis; ; metanephric glomerulus; ; secondary oocyte; ; spinal ganglia; ; caput epididymis; ; inferior ganglion of vagus nerve; ; seminal vesicula; ; inferior olivary nucleus; ; trigeminal ganglion; ; kidney tubule;
	Top expressed in
	trigeminal ganglion; ; germinal epithelium; ; primitive streak; ; somatopleuric mesenchyme; ; Bowman's capsule; ; medullary collecting duct; ; mucosa of large intestine; ; dorsal mesentery; ; enteric nervous system; ; Epithelium of large intestine;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	sequence-specific DNA binding; DNA binding; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	nucleus; nucleoplasm;
Biological process	multicellular organism development; sensory perception of pain; regulation of transcription, DNA-templated; transcription, DNA-templated; neuron differentiation; embryonic skeletal system development; regulation of transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologs
	3231
	15429
	ENSG00000128645
	ENSMUSG00000042448
	Q9GZZ0
	Q01822
	NM_024501
	NM_010467
	NP_078777
	NP_034597
	Wikidata
View/Edit Human	View/Edit Mouse

Homeobox protein Hox-D1 is a protein that in humans is encoded by the HOXD1 gene.^[5]^[6]^[7]

This gene is a member of the Antp homeobox family and encodes a protein with a homeobox DNA-binding domain. This nuclear protein functions as a sequence-specific transcription factor that is involved in differentiation and limb development. Mutations in this gene have been associated with severe developmental defects on the anterior-posterior (a-p) limb axis.^[7]

References

^ a b c GRCh38: Ensembl release 89: ENSG00000128645 – Ensembl, May 2017
^ a b c GRCm38: Ensembl release 89: ENSMUSG00000042448 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ McAlpine PJ, Shows TB (Aug 1990). "Nomenclature for human homeobox genes". Genomics. 7 (3): 460. doi:10.1016/0888-7543(90)90186-X. PMID 1973146.
^ Scott MP (Dec 1992). "Vertebrate homeobox gene nomenclature". Cell. 71 (4): 551–3. doi:10.1016/0092-8674(92)90588-4. PMID 1358459. S2CID 13370372.
^ a b "Entrez Gene: HOXD1 homeobox D1".

External links

HOXD1+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article on a gene on human chromosome 2 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000128645 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000042448 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1973146-5] McAlpine PJ, Shows TB (Aug 1990). "Nomenclature for human homeobox genes". Genomics. 7 (3): 460. doi:10.1016/0888-7543(90)90186-X. PMID 1973146.

[pmid1358459-6] Scott MP (Dec 1992). "Vertebrate homeobox gene nomenclature". Cell. 71 (4): 551–3. doi:10.1016/0092-8674(92)90588-4. PMID 1358459. S2CID 13370372.

[entrez-7] "Entrez Gene: HOXD1 homeobox D1".

HOXD1

See also

References

Further reading

External links