HMG20B

HMG20B
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2CRJ
Identifiers
Aliases	HMG20B, BRAF25, BRAF35, HMGX2, HMGXB2, PP7706, SMARCE1r, SOXL, pp8857, high mobility group 20B
External IDs	OMIM: 605535 MGI: 1341190 HomoloGene: 74949 GeneCards: HMG20B
Gene location (Human)
Chr.	Chromosome 19 (human)
End	3,579,088 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	81,186,314 bp
RNA expression pattern
	Top expressed in
	sural nerve; ; stromal cell of endometrium; ; canal of the cervix; ; popliteal artery; ; skin of abdomen; ; right uterine tube; ; thoracic aorta; ; ascending aorta; ; transverse colon; ; minor salivary glands;
	Top expressed in
	interventricular septum; ; lip; ; yolk sac; ; lens; ; internal carotid artery; ; duodenum; ; thymus; ; intestinal villus; ; external carotid artery; ; neural tube;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	protein heterodimerization activity; DNA binding; protein binding; histone deacetylase activity; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	nucleus; nucleoplasm; chromosome; nuclear body;
Biological process	skeletal muscle cell differentiation; cell cycle; negative regulation of protein sumoylation; blood coagulation; regulation of transcription, DNA-templated; positive regulation of neuron differentiation; transcription, DNA-templated; histone deacetylation; chromatin organization; regulation of transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologs
	10362
	15353
	ENSG00000064961
	ENSMUSG00000020232
	Q9P0W2
	Q9Z104
	NM_006339
	NM_001163165; NM_001163166; NM_010440
	NP_006330
	NP_001156637; NP_001156638; NP_034570
	Wikidata
View/Edit Human	View/Edit Mouse

SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1-related is a protein that in humans is encoded by the HMG20B gene.^[5]^[6]

HMG20B is a high-mobility group (HMG) DNA binding protein. HMG20B contains a carboxy terminal region that is essential for cytokinesis since it regulates cell cycle progression from the G2 phase into mitosis^[7] This carboxy terminal region of HMG20B interacts with the tumor suppressor protein BRCA2. A particular mutation in this region of the HMG20B gene is associated with lung cancer. This mutation interferes with the association of the HMG20B and BRCA2 proteins.^[7]

Interactions

HMG20B has been shown to interact with:

BRCA2,^[8]^[9]
HDAC1,^[8]
HDAC2,^[8]^[10]
KIF4A,^[11]
PHF21A,^[8]^[12] and
RCOR1.^[8]

References

^ a b c GRCh38: Ensembl release 89: ENSG00000064961 – Ensembl, May 2017
^ a b c GRCm38: Ensembl release 89: ENSMUSG00000020232 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Sumoy L, Carim L, Escarceller M, Nadal M, Gratacòs M, Pujana MA, Estivill X, Peral B (Jun 2000). "HMG20A and HMG20B map to human chromosomes 15q24 and 19p13.3 and constitute a distinct class of HMG-box genes with ubiquitous expression". Cytogenetics and Cell Genetics. 88 (1–2): 62–7. doi:10.1159/000015486. PMID 10773667. S2CID 22921110.
^ "Entrez Gene: HMG20B high-mobility group 20B".
^ a b Lee M, Venkitaraman AR (2014). "A cancer-associated mutation inactivates a region of the high-mobility group protein HMG20b essential for cytokinesis". Cell Cycle. 13 (16): 2554–63. doi:10.4161/15384101.2014.942204. PMC 4614378. PMID 25486196.
^ a b c d e Hakimi MA, Bochar DA, Chenoweth J, Lane WS, Mandel G, Shiekhattar R (May 2002). "A core-BRAF35 complex containing histone deacetylase mediates repression of neuronal-specific genes". Proceedings of the National Academy of Sciences of the United States of America. 99 (11): 7420–5. Bibcode:2002PNAS...99.7420H. doi:10.1073/pnas.112008599. PMC 124246. PMID 12032298.
^ Marmorstein LY, Kinev AV, Chan GK, Bochar DA, Beniya H, Epstein JA, Yen TJ, Shiekhattar R (January 2001). "A human BRCA2 complex containing a structural DNA binding component influences cell cycle progression". Cell. 104 (2): 247–57. doi:10.1016/S0092-8674(01)00209-4. PMID 11207365. S2CID 5822368.
^ Hakimi MA, Dong Y, Lane WS, Speicher DW, Shiekhattar R (February 2003). "A candidate X-linked mental retardation gene is a component of a new family of histone deacetylase-containing complexes". The Journal of Biological Chemistry. 278 (9): 7234–9. doi:10.1074/jbc.M208992200. PMID 12493763.
^ Lee YM, Kim W (September 2003). "Association of human kinesin superfamily protein member 4 with BRCA2-associated factor 35". The Biochemical Journal. 374 (Pt 2): 497–503. doi:10.1042/BJ20030452. PMC 1223617. PMID 12809554.
^ Iwase S, Januma A, Miyamoto K, Shono N, Honda A, Yanagisawa J, Baba T (September 2004). "Characterization of BHC80 in BRAF-HDAC complex, involved in neuron-specific gene repression". Biochemical and Biophysical Research Communications. 322 (2): 601–8. doi:10.1016/j.bbrc.2004.07.163. PMID 15325272.

External links

HMG20B human gene location in the UCSC Genome Browser.
HMG20B human gene details in the UCSC Genome Browser.

This article on a gene on human chromosome 19 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000064961 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000020232 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10773667-5] Sumoy L, Carim L, Escarceller M, Nadal M, Gratacòs M, Pujana MA, Estivill X, Peral B (Jun 2000). "HMG20A and HMG20B map to human chromosomes 15q24 and 19p13.3 and constitute a distinct class of HMG-box genes with ubiquitous expression". Cytogenetics and Cell Genetics. 88 (1–2): 62–7. doi:10.1159/000015486. PMID 10773667. S2CID 22921110.

[entrez-6] "Entrez Gene: HMG20B high-mobility group 20B".

[Lee2014-7] Lee M, Venkitaraman AR (2014). "A cancer-associated mutation inactivates a region of the high-mobility group protein HMG20b essential for cytokinesis". Cell Cycle. 13 (16): 2554–63. doi:10.4161/15384101.2014.942204. PMC 4614378. PMID 25486196.

[pmid12032298-8] Hakimi MA, Bochar DA, Chenoweth J, Lane WS, Mandel G, Shiekhattar R (May 2002). "A core-BRAF35 complex containing histone deacetylase mediates repression of neuronal-specific genes". Proceedings of the National Academy of Sciences of the United States of America. 99 (11): 7420–5. Bibcode:2002PNAS...99.7420H. doi:10.1073/pnas.112008599. PMC 124246. PMID 12032298.

[pmid11207365-9] Marmorstein LY, Kinev AV, Chan GK, Bochar DA, Beniya H, Epstein JA, Yen TJ, Shiekhattar R (January 2001). "A human BRCA2 complex containing a structural DNA binding component influences cell cycle progression". Cell. 104 (2): 247–57. doi:10.1016/S0092-8674(01)00209-4. PMID 11207365. S2CID 5822368.

[pmid12493763-10] Hakimi MA, Dong Y, Lane WS, Speicher DW, Shiekhattar R (February 2003). "A candidate X-linked mental retardation gene is a component of a new family of histone deacetylase-containing complexes". The Journal of Biological Chemistry. 278 (9): 7234–9. doi:10.1074/jbc.M208992200. PMID 12493763.

[pmid12809554-11] Lee YM, Kim W (September 2003). "Association of human kinesin superfamily protein member 4 with BRCA2-associated factor 35". The Biochemical Journal. 374 (Pt 2): 497–503. doi:10.1042/BJ20030452. PMC 1223617. PMID 12809554.

[pmid15325272-12] Iwase S, Januma A, Miyamoto K, Shono N, Honda A, Yanagisawa J, Baba T (September 2004). "Characterization of BHC80 in BRAF-HDAC complex, involved in neuron-specific gene repression". Biochemical and Biophysical Research Communications. 322 (2): 601–8. doi:10.1016/j.bbrc.2004.07.163. PMID 15325272.

HMG20B

Interactions

References

Further reading

External links