GZMB

GZMB
Available structures
PDB	Human UniProt search: PDBe RCSB
List of PDB id codes
	1FQ3, 1IAU
Identifiers
Aliases	GZMB, CCPI, CGL-1, CGL1, CSP-B, CSPB, CTLA1, CTSGL1, HLP, SECT, granzyme B, C11
External IDs	OMIM: 123910 HomoloGene: 108184 GeneCards: GZMB
Gene location (Human)
Chr.	Chromosome 14 (human)
End	24,634,267 bp
RNA expression pattern
	Top expressed in
	blood; ; monocyte; ; spleen; ; bone marrow; ; lymph node; ; right lung; ; appendix; ; palpebral conjunctiva; ; upper lobe of left lung; ; bone marrow cells;
	n/a
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	peptidase activity; protein binding; serine-type peptidase activity; serine-type endopeptidase activity; hydrolase activity;
Cellular component	cytosol; membrane; immunological synapse; nucleus; mitochondrion; secretory granule; cytoplasm;
Biological process	cytolysis; proteolysis; positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway; natural killer cell mediated cytotoxicity; apoptotic process; granzyme-mediated apoptotic signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	3002
	n/a
	ENSG00000100453
	n/a
	P10144
	n/a
	NM_004131; NM_001346011
	n/a
	NP_001332940; NP_004122
	n/a
	Wikidata
View/Edit Human

Granzyme B is a serine protease that in humans is encoded by the GZMB gene.^[3] Granzyme B is expressed by cytotoxic T lymphocytes (CTL) and natural killer (NK) cells.

CTL and NK cells share the remarkable ability to recognize specific infected target cells. They are thought to protect their host by inducing apoptosis of cells that bear on their surface 'nonself' antigens, usually peptides or proteins resulting from infection by intracellular pathogens. The protein encoded by this gene is crucial for the rapid induction of target cell apoptosis by CTL in cell-mediated immune response.^[4]

References

^ a b c GRCh38: Ensembl release 89: ENSG00000100453 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Dahl CA, Bach FH, Chan W, Huebner K, Russo G, Croce CM, Herfurth T, Cairns JS (May 1990). "Isolation of a cDNA clone encoding a novel form of granzyme B from human NK cells and mapping to chromosome 14". Hum Genet. 84 (5): 465–70. doi:10.1007/bf00195821. PMID 2323780. S2CID 22245529.
^ "Entrez Gene: GZMB granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)".

External links

The MEROPS online database for peptidases and their inhibitors: S01.010

This article on a gene on human chromosome 14 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000100453 – Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid2323780-3] Dahl CA, Bach FH, Chan W, Huebner K, Russo G, Croce CM, Herfurth T, Cairns JS (May 1990). "Isolation of a cDNA clone encoding a novel form of granzyme B from human NK cells and mapping to chromosome 14". Hum Genet. 84 (5): 465–70. doi:10.1007/bf00195821. PMID 2323780. S2CID 22245529.

[4] "Entrez Gene: GZMB granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)".

GZMB

See also

References

Further reading

External links