Protein-coding gene in the species Homo sapiens
| GUF1 |
|---|
|
| Identifiers |
|---|
| Aliases | GUF1, EF-4, GUF1 homolog, GTPase, EIEE40, EF4, GTP binding elongation factor DEE40 |
|---|
| External IDs | OMIM: 617064 MGI: 2140726 HomoloGene: 6505 GeneCards: GUF1 |
|---|
|
| Gene location (Mouse) |
|---|
 | | Chr. | Chromosome 5 (mouse)[2] |
|---|
| | Band | 5|5 C3.1 | Start | 69,714,266 bp[2] |
|---|
| End | 69,733,316 bp[2] |
|---|
|
| RNA expression pattern |
|---|
| Bgee | | Human | Mouse (ortholog) |
|---|
| Top expressed in | - gastrocnemius muscle
- biceps brachii
- ganglionic eminence
- Achilles tendon
- rectum
- oral cavity
- amygdala
- stromal cell of endometrium
- dorsolateral prefrontal cortex
- right ventricle
|
| | Top expressed in | - hand
- otolith organ
- utricle
- lens
- superior frontal gyrus
- neural tube
- proximal tubule
- cerebellar cortex
- esophagus
- ganglionic eminence
|
| | More reference expression data |
|
|---|
| BioGPS | |
|---|
|
| Gene ontology |
|---|
| Molecular function |
- nucleotide binding
- GTP binding
- hydrolase activity
- GTPase activity
- ribosome binding
| | Cellular component |
- mitochondrial inner membrane
- membrane
- mitochondrion
- mitochondrial matrix
| | Biological process |
- protein biosynthesis
- positive regulation of translation
| | Sources:Amigo / QuickGO |
|
| Orthologs |
|---|
| Species | Human | Mouse |
|---|
| Entrez | | |
|---|
| Ensembl | | |
|---|
| UniProt | | |
|---|
| RefSeq (mRNA) | |
|---|
NM_021927
NM_001345867
NM_001345868
NM_001345869 |
| |
|---|
NM_172711
NM_182768
NM_001310631 |
|
|---|
| RefSeq (protein) | |
|---|
NP_001332796
NP_001332797
NP_001332798
NP_068746 |
| |
|---|
| Location (UCSC) | Chr 4: 44.68 – 44.7 Mb | Chr 5: 69.71 – 69.73 Mb |
|---|
| PubMed search | [3] | [4] |
|---|
|
| Wikidata |
| View/Edit Human | View/Edit Mouse |
|
GUF1 homolog, GTPase is a protein that in humans is encoded by the GUF1 gene.
[5] It is the mitochondrial homolog of elongation factor 4.
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000151806 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000029208 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^
"Entrez Gene: GUF1 homolog, GTPase". Retrieved 2016-09-01.
Further reading
- Hendrickson SL, Lautenberger JA, Chinn LW, Malasky M, Sezgin E, Kingsley LA, Goedert JJ, Kirk GD, Gomperts ED, Buchbinder SP, Troyer JL, O'Brien SJ (2010). "Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression". PLOS ONE. 5 (9): e12862. Bibcode:2010PLoSO...512862H. doi:10.1371/journal.pone.0012862. PMC 2943476. PMID 20877624.
