File:Complement pathway.svg

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Summary

Description
English: The complement system is made up of about 25 proteins that work together to “complement” the action of antibodies in destroying bacteria. Complement proteins circulate in the blood in an inactive form. When the first protein in the complement series is activated— typically by antibody that has locked onto an antigen—it sets in motion a domino effect. Each component takes its turn in a precise chain of steps known as the complement cascade. The end product is a cylinder inserted into—and puncturing a hole in—the cell’s wall. With fluids and molecules flowing in and out, the cell swells and bursts.
Deutsch: Das Komplementsystem besteht aus etwa 25 Proteinen, die zusammen die Immunantwort von Antikörpern ergänzen (komplementieren) um so Bakterien zu zerstören. Komplement-Proteine zirkulieren in einer inaktiven Form im Blut. Wenn das erste Protein der Komplement-Kaskade aktiviert wird - typischerweise durch einen Antikörper, der an ein Antigen gebunden hat, kommt es zu einem Domino-Effekt. Jede Komponente aktiviert die nachfolgende in einer Kette von Schritten, die als Komplement-Kaskade bezeichnet wird. Das Endprodukt ist ein Zylinder in der Membran der Zielzelle, der ein Loch in die Zellmembran stanzt. Dies führt zum Austausch von Molekülen und Flüssigkeit zwischen Zellinnerem und Umgebung, die Zelle schwillt an und platzt.
Nederlands: Complementsysteem
Čeština: Komplement sestává z neaktivních proteinů, které se aktivují kaskádovitě třemi známými cestami - alternativní, klasickou a lektinovou. Doplňuje imunitní protilátkovou odpověď proti bakteriím.
Français : Le Système du complément est composé d'environ 25 protéines travaillant ensemble pour "compléter" l'action anti-bactérienne des anticorps. Ces protéines circulent dans le sang sous forme inactive. Lorsque la première de la série est activée, typiquement par un anticorps ayant capté un antigène, les autres s'activent par effet domino : chaque complément prend effet tour à tour en cascade. Le résultat final est un cylindre transperçant la paroi de la cellule. Les fluides et molécules circulent alors librement entre l'intérieur et l'extérieur, faisant gonfler la cellule jusqu'à son explosion.
Date NIH Publication No. 03–5423, September 2003 (modifications: September 4, 2006) (SVG 1 December 2015)
Source Own work based on: http://www.niaid.nih.gov/publications/immune/the_immune_system.pdf
Author
  • English text of 'Image:Complement pathway.png' by DO11.10
  • German translation of 'Image:Complement pathway.png' by Hduman
  • Galician translation Miguelferig
  • Catalan translation Leptictidium
  • Spanish translation Asierog
  • SVG by Perhelion
Permission
(Reusing this file)
Original work of the US Federal Government - public domain
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complement system

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File history

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Date/TimeThumbnailDimensionsUserComment
current00:53, 29 September 20201,680 × 2,024 (26 KB)AsierogSpanish translation added, C2a changed for C2b in all languages
12:16, 6 February 20201,680 × 2,024 (24 KB)WhidouAdd French translation
14:29, 16 June 20191,680 × 2,024 (23 KB)SMPCatalan spelling
01:33, 6 September 20161,680 × 2,024 (23 KB)DadOfBeanAndBugReverted to version as of 01:30, 6 September 2016 (UTC)
01:31, 6 September 20161,680 × 2,024 (23 KB)DadOfBeanAndBugReverted to version as of 20:44, 1 December 2015 (UTC)
01:30, 6 September 20161,680 × 2,024 (23 KB)DadOfBeanAndBugen: changed membran -> membrane
20:44, 1 December 20151,680 × 2,024 (23 KB)Perhelionlang +ca +gl (+fix de)
12:38, 1 December 20151,680 × 2,020 (20 KB)Perhelionminor tweak
01:40, 1 December 20151,680 × 2,020 (27 KB)Perhelion=={{int:filedesc}}== {{Information |Description= {{en|The complement system is made up of about 25 proteins that work together to “complement” the action of antibodies in destroying bacteria. Complement proteins circulate in the blood in an inactiv...

Global file usage

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  • Usage on ar.wikipedia.org
    • جملة المتممة
    • سبيل تقليدي متمم
    • المسار المكمل البديل في الجهاز المناعي
  • Usage on bs.wikipedia.org
    • Komplementni sistem
  • Usage on ca.wikipedia.org
    • Sistema del complement
    • Portal:Immunologia/Imatges
    • Plantilla:Imatge immunològica del mes 8
    • Zimogen
    • Proteïna d'unió a C4b
  • Usage on cs.wikipedia.org
    • Komplement (biologie)
    • C3 konvertáza
  • Usage on de.wikipedia.org
    • Komplementsystem
    • Krebsimmuntherapie
    • Wikipedia:Grafikwerkstatt/Archiv/2015/November
  • Usage on de.wikibooks.org
    • Benutzer:OnkelDagobert:Wikilinks:Innere Medizin
    • Sammlung Medizin: Nervensystem
    • Sammlung Medizin: Leber
  • Usage on es.wikipedia.org
    • Sistema del complemento
  • Usage on fa.wikipedia.org
    • جزء سوم کمپلمان
    • کمبود کمپلمان
  • Usage on fr.wikipedia.org
    • Système du complément
  • Usage on gl.wikipedia.org
    • Complemento (inmunidade)
    • Cimóxeno
    • Convertase de C3
  • Usage on he.wikipedia.org
    • Streptococcus pyogenes
  • Usage on hy.wikipedia.org
    • Արյան կոմպլեմենտի համակարգ
  • Usage on ja.wikipedia.org
    • 補体第1成分
  • Usage on ko.wikipedia.org
    • 보체
  • Usage on mk.wikipedia.org
    • Систем на комплемент
    • C1 комплекс
  • Usage on nl.wikipedia.org
    • Complementsysteem
  • Usage on pl.wikipedia.org
    • Konwertaza C3
    • Konwertaza C5
  • Usage on pt.wikipedia.org
    • C3b
    • Via alternativa do sistema complemento
  • Usage on ru.wikipedia.org
    • Проект:Графическая мастерская/Заявки/Архив/2020/03
  • Usage on sh.wikipedia.org
    • Komponenta komplementa 3a
  • Usage on sr.wikipedia.org
    • Komponenta komplementa 3a
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    • Kompleman sistemi
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