Protein-coding gene in the species Homo sapiens
OTULIN |
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Available structures |
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PDB | Ortholog search: PDBe RCSB |
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List of PDB id codes |
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3ZNV, 3ZNX, 3ZNZ, 4KSJ, 4KSK, 4KSL, 4OYK, 4P0B |
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Identifiers |
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Aliases | OTULIN, FAM105B, GUM, OTU deubiquitinase with linear linkage specificity, AIPDS |
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External IDs | OMIM: 615712 MGI: 3577015 HomoloGene: 106591 GeneCards: OTULIN |
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Gene location (Mouse) |
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| Chr. | Chromosome 15 (mouse)[2] |
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| Band | 15|15 B1 | Start | 27,542,721 bp[2] |
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End | 27,630,779 bp[2] |
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RNA expression pattern |
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Bgee | Human | Mouse (ortholog) |
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Top expressed in | - bone marrow cells
- pancreatic ductal cell
- sural nerve
- monocyte
- Achilles tendon
- thymus
- skin of abdomen
- blood
- tibialis anterior muscle
- lymph node
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| Top expressed in | - yolk sac
- left lobe of liver
- saccule
- spermatid
- soleus muscle
- proximal tubule
- otic placode
- spleen
- lip
- primitive streak
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| More reference expression data |
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BioGPS | |
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Gene ontology |
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Molecular function |
- cysteine-type peptidase activity
- thiol-dependent deubiquitinase
- peptidase activity
- protein binding
- hydrolase activity
| Cellular component |
- cytosol
- LUBAC complex
- cytoplasm
| Biological process |
- immune system process
- Wnt signaling pathway
- proteolysis
- nucleotide-binding oligomerization domain containing 2 signaling pathway
- angiogenesis
- canonical Wnt signaling pathway
- sprouting angiogenesis
- protein linear deubiquitination
- regulation of tumor necrosis factor-mediated signaling pathway
- negative regulation of NF-kappaB transcription factor activity
- innate immune response
- negative regulation of inflammatory response
- regulation of canonical Wnt signaling pathway
- protein ubiquitination
| Sources:Amigo / QuickGO |
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Wikidata |
View/Edit Human | View/Edit Mouse |
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Family with sequence similarity 105, member B is a protein in humans that is encoded by the FAM105B gene.
[5]
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000154124 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000046034 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^
"Entrez Gene: Family with sequence similarity 105, member B". Retrieved 2012-11-19.
Further reading