Protein found in humans
C7 Available structures PDB Ortholog search: PDBe RCSB
Identifiers Aliases C7 , complement component 7, complement C7External IDs OMIM : 217070 MGI : 88235 HomoloGene : 489 GeneCards : C7 Gene location (Mouse ) Chr. Chromosome 15 (mouse)[2] Band 15 A1|15 1.98 cM Start 5,018,244 bp [2] End 5,093,222 bp [2]
RNA expression patternBgee Human Mouse (ortholog)Top expressed in superficial temporal artery pericardium gastric mucosa left adrenal gland gallbladder right coronary artery left uterine tube lower lobe of lung peritoneum left coronary artery
Top expressed in zone of skin spermatid esophagus lung testicle spermatocyte white adipose tissue skeletal muscle tissue adrenal gland quadriceps femoris muscle
More reference expression data
BioGPS
Gene ontology Molecular function Cellular component
extracellular region
extracellular exosome
membrane attack complex
Biological process
complement activation
cytolysis
regulation of complement activation
complement activation, alternative pathway
immune response
complement activation, classical pathway
immune system process
innate immune response
cellular sodium ion homeostasis
Sources:Amigo / QuickGO
Wikidata View/Edit Human View/Edit Mouse
Complement component 7 is a protein involved in the complement system of the innate immune system . C7 is part of the membrane attack complex (MAC) which creates a hole on pathogen surfaces, leading to cell lysis and death.
Its primary task is to bind the C5bC6 complex together. This junction alters the configuration of the protein molecules, exposing a hydrophobic site on C7 that allows the C7 to insert into the phospholipid bilayer of the pathogen.
See also
External links
Complement+C7 at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
Overview of all the structural information available in the PDB for UniProt : P10643 (Human Complement component C7) at the PDBe-KB .
References
^ a b c GRCh38: Ensembl release 89: ENSG00000112936 – Ensembl , May 2017
^ a b c GRCm38: Ensembl release 89: ENSMUSG00000079105 – Ensembl , May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine .
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine .