Basophilic stippling
Basophilic stippling, also known as punctate basophilia, is the presence of numerous basophilic granules that are dispersed through the cytoplasm of erythrocytes in a peripheral blood smear. They can be demonstrated to be RNA. They are composed of aggregates of ribosomes; degenerating mitochondria and siderosomes may be included in the aggregates.[citation needed] In contrast to Pappenheimer bodies, they are negative with Perls' acid ferrocyanide stain for iron (i.e. no iron in basophilic stippling).[1] Basophilic stippling is indicative of disturbed erythropoiesis. It can also be found in some normal individuals.[2]
Associated conditions
- Thalassemia[3] (β-thalassemia Minor (i.e. Trait) & Major, and α-thalassemia, only when 3 gene loci defective: (--/-α))
- Severe megaloblastic anemia
- Hemolytic anemia
- Sickle-cell anemia
- Pyrimidine 5' nucleotidase deficiency[4]
- Alcoholism[5]
- Myelodysplastic syndromes
- Sideroblastic anemia[6]
- Congenital dyserythropoietic anemia[7]
- Primary myelofibrosis
- Leukemia[8]
- Erythroleukemia[9]
- Hemorrhage, e.g. from gastrointestinal tract
- CPD-choline phosphotransferase deficiency[10]
- Unstable hemoglobins
- Altered hemoglobin biosynthesis
- Heavy metal poisoning[11][12]
References
- ^ Le, Tao; Bhushan, Vikas; Coleman, Caroline; Jones, Stepanie; Kaparaliotis, Panagiotis; Kallianos, Kimberly, eds. (2023). First Aid for the® USMLE® Step 1 2023 (33rd ed.). New York Chicago San Francisco: McGraw Hill. p. 422. ISBN 978-1-264-94662-4.
- ^ Cheson, B. D; Rom, W. N; Webber, R. C (1984). "Basophilic stippling of red blood cells: A nonspecific finding of multiple etiology". American Journal of Industrial Medicine. 5 (4): 327–34. doi:10.1002/ajim.4700050409. PMID 6202140.
- ^ Tkachuk, Douglas C.; Hirschmann, Jan V.; Wintrobe, Maxwell Myer (2007). Wintrobe's Atlas of Clinical Hematology. Lippincott Williams & Wilkins. ISBN 9780781770231.[page needed]
- ^ Seip, M (1999). "Pyrimidine-5'-nucleotidase deficiency--congenital hemolytic anemia with basophilic stippling of erythrocytes". Tidsskrift for den Norske Laegeforening. 119 (20): 2996–8. PMID 10504847.
- ^ Chernecky, Cynthia C.; Berger, Barbara J. (2007-06-14). Laboratory Tests and Diagnostic Procedures. Elsevier Health Sciences. ISBN 978-1416066835.
- ^ Rodak, Bernadette F. (2007). Hematology : clinical principles and applications (3rd ed.). Philadelphia: Saunders. p. 535. ISBN 978-1416030065.
- ^ Kliegman, Robert M.; Stanton, Bonita M. D.; Geme, Joseph St; Schor, Nina F.; Behrman, Richard E. (2011-06-01). Nelson Textbook of Pediatrics E-Book. Elsevier Health Sciences. ISBN 978-1437735895.[page needed]
- ^ Chernecky, Cynthia C.; Berger, Barbara J. (2007-06-14). Laboratory Tests and Diagnostic Procedures. Elsevier Health Sciences. ISBN 978-1416066835.[page needed]
- ^ Chernecky, Cynthia C.; Berger, Barbara J. (2007-06-14). Laboratory Tests and Diagnostic Procedures. Elsevier Health Sciences. ISBN 978-1416066835.[page needed]
- ^ Porwit, Anna; McCullough, Jeffrey; Erber, Wendy N. (2011-05-27). Blood and Bone Marrow Pathology E-Book. Elsevier Health Sciences. ISBN 978-0702045356.[page needed]
- ^ Keohane, Elaine; Smith, Larry; Walenga, Jeanine (2015-02-19). Rodak's Hematology - E-Book: Clinical Principles and Applications. Elsevier Health Sciences. ISBN 9780323327169.[page needed]
- ^ Fleisher, Gary Robert; Ludwig, Stephen; Silverman, Benjamin K. (2002). Synopsis of Pediatric Emergency Medicine. Lippincott Williams & Wilkins. ISBN 9780781732741.[page needed]