Basal cell adhesion molecule

BCAM
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2PET, 2PF6
Identifiers
Aliases	BCAM, AU, CD239, LU, MSK19, basal cell adhesion molecule (Lutheran blood group)
External IDs	OMIM: 612773 MGI: 1929940 HomoloGene: 21149 GeneCards: BCAM
Gene location (Human)
Chr.	Chromosome 19 (human)
End	44,821,421 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	19,504,941 bp
RNA expression pattern
	Top expressed in
	right uterine tube; ; left lobe of thyroid gland; ; popliteal artery; ; right lobe of thyroid gland; ; right coronary artery; ; renal medulla; ; left coronary artery; ; canal of the cervix; ; left uterine tube; ; kidney;
	Top expressed in
	interventricular septum; ; lip; ; molar; ; right lung; ; left lung; ; right lung lobe; ; left lung lobe; ; cardiac muscles; ; atrium; ; right ventricle;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	laminin receptor activity; protein C-terminus binding; protein binding; laminin binding; transmembrane signaling receptor activity;
Cellular component	integral component of membrane; cell surface; plasma membrane; integral component of plasma membrane; extracellular exosome; membrane; external side of plasma membrane; extracellular matrix; extracellular region; collagen-containing extracellular matrix;
Biological process	cell adhesion; cell-matrix adhesion; signal transduction;
	Sources:Amigo / QuickGO
Orthologs
	4059
	57278
	ENSG00000187244
	ENSMUSG00000002980
	P50895
	Q9R069
	NM_005581; NM_001013257
	NM_020486
	NP_001013275; NP_005572
	NP_065232
	Wikidata
View/Edit Human	View/Edit Mouse

Basal cell adhesion molecule, also known as Lutheran antigen, is a plasma membrane glycoprotein that in humans is encoded by the BCAM gene.^[5] BCAM has also recently been designated CD239 (cluster of differentiation 239).

Function

Lutheran blood group glycoprotein is a member of the immunoglobulin superfamily and a receptor for the extracellular matrix protein, laminin. The protein contains five, N-terminus, extracellular immunoglobulin domains, a single transmembrane domain, and a short, C-terminal cytoplasmic tail. This protein may play a role in epithelial cell cancer and in vaso-occlusion of red blood cells in sickle cell disease. Two transcript variants encoding different isoforms have been found for this gene.^[5]

Interactions

BCAM has been shown to interact with Laminin, alpha 5. BCAM has also been shown to promote the metastasis of ovarian cancer.^[6]^[7]^[8]

References

^ a b c GRCh38: Ensembl release 89: ENSG00000187244 – Ensembl, May 2017
^ a b c GRCm38: Ensembl release 89: ENSMUSG00000002980 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ a b "Entrez Gene: BCAM basal cell adhesion molecule (Lutheran blood group)".
^ Parsons SF, Lee G, Spring FA, Willig TN, Peters LL, Gimm JA, Tanner MJ, Mohandas N, Anstee DJ, Chasis JA (2001). "Lutheran blood group glycoprotein and its newly characterized mouse homologue specifically bind alpha5 chain-containing human laminin with high affinity". Blood. 97 (1): 312–20. doi:10.1182/blood.v97.1.312. PMID 11133776. S2CID 10715366.
^ Kikkawa Y, Moulson CL, Virtanen I, Miner JH (2002). "Identification of the binding site for the Lutheran blood group glycoprotein on laminin alpha 5 through expression of chimeric laminin chains in vivo". J. Biol. Chem. 277 (47): 44864–9. doi:10.1074/jbc.M208731200. PMID 12244066.
^ Sivakumar S, Lieber S, Librizzi D (2023). "Basal cell adhesion molecule promotes metastasis-associated processes in ovarian cancer". Clin Transl Med. 13 (1): e1176. doi:10.1002/ctm2.1176. PMC 9842900. PMID 36647260.

Eyler CE, Telen MJ (2006). "The Lutheran glycoprotein: a multifunctional adhesion receptor". Transfusion. 46 (4): 668–77. doi:10.1111/j.1537-2995.2006.00779.x. PMID 16584446. S2CID 37594599.
Lewis M, Kaita H, Coghlan G, et al. (1989). "The chromosome 19 linkage group LDLR, C3, LW, APOC2, LU, SE in man". Ann. Hum. Genet. 52 (Pt 2): 137–44. doi:10.1111/j.1469-1809.1988.tb01089.x. PMID 2907851. S2CID 26927877.
Parsons SF, Mallinson G, Holmes CH, et al. (1995). "The Lutheran blood group glycoprotein, another member of the immunoglobulin superfamily, is widely expressed in human tissues and is developmentally regulated in human liver". Proc. Natl. Acad. Sci. U.S.A. 92 (12): 5496–500. Bibcode:1995PNAS...92.5496P. doi:10.1073/pnas.92.12.5496. PMC 41722. PMID 7777537.
Campbell IG, Foulkes WD, Senger G, et al. (1994). "Molecular cloning of the B-CAM cell surface glycoprotein of epithelial cancers: a novel member of the immunoglobulin superfamily". Cancer Res. 54 (22): 5761–5. PMID 7954395.
Rahuel C, Le Van Kim C, Mattei MG, et al. (1996). "A unique gene encodes spliceoforms of the B-cell adhesion molecule cell surface glycoprotein of epithelial cancer and of the Lutheran blood group glycoprotein". Blood. 88 (5): 1865–72. doi:10.1182/blood.V88.5.1865.1865. PMID 8781446.
Parsons SF, Mallinson G, Daniels GL, et al. (1997). "Use of domain-deletion mutants to locate Lutheran blood group antigens to each of the five immunoglobulin superfamily domains of the Lutheran glycoprotein: elucidation of the molecular basis of the Lu(a)/Lu(b) and the Au(a)/Au(b) polymorphisms". Blood. 89 (11): 4219–25. doi:10.1182/blood.V89.11.4219. PMID 9166867.
El Nemer W, Rahuel C, Colin Y, et al. (1997). "Organization of the human LU gene and molecular basis of the Lu(a)/Lu(b) blood group polymorphism". Blood. 89 (12): 4608–16. doi:10.1182/blood.V89.12.4608. PMID 9192786.
Parsons SF, Lee G, Spring FA, et al. (2001). "Lutheran blood group glycoprotein and its newly characterized mouse homologue specifically bind alpha5 chain-containing human laminin with high affinity". Blood. 97 (1): 312–20. doi:10.1182/blood.V97.1.312. PMID 11133776. S2CID 10715366.
El Nemer W, Gane P, Colin Y, et al. (2001). "Characterization of the laminin binding domains of the Lutheran blood group glycoprotein". J. Biol. Chem. 276 (26): 23757–62. doi:10.1074/jbc.M102978200. PMID 11319237.
Kikkawa Y, Moulson CL, Virtanen I, Miner JH (2003). "Identification of the binding site for the Lutheran blood group glycoprotein on laminin alpha 5 through expression of chimeric laminin chains in vivo". J. Biol. Chem. 277 (47): 44864–9. doi:10.1074/jbc.M208731200. PMID 12244066.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Shin BK, Wang H, Yim AM, et al. (2003). "Global profiling of the cell surface proteome of cancer cells uncovers an abundance of proteins with chaperone function". J. Biol. Chem. 278 (9): 7607–16. doi:10.1074/jbc.M210455200. PMID 12493773.
Zhang H, Li XJ, Martin DB, Aebersold R (2003). "Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry". Nat. Biotechnol. 21 (6): 660–6. doi:10.1038/nbt827. PMID 12754519. S2CID 581283.
Crew VK, Green C, Daniels G (2004). "Molecular bases of the antigens of the Lutheran blood group system". Transfusion. 43 (12): 1729–37. doi:10.1111/j.0041-1132.2003.00600.x. PMID 14641871. S2CID 23121476.
Zen Q, Batchvarova M, Twyman CA, et al. (2004). "B-CAM/LU expression and the role of B-CAM/LU activation in binding of low- and high-density red cells to laminin in sickle cell disease". Am. J. Hematol. 75 (2): 63–72. doi:10.1002/ajh.10442. PMID 14755370. S2CID 25313713.
Kroviarski Y, El Nemer W, Gane P, et al. (2004). "Direct interaction between the Lu/B-CAM adhesion glycoproteins and erythroid spectrin". Br. J. Haematol. 126 (2): 255–64. doi:10.1111/j.1365-2141.2004.05010.x. PMID 15238148. S2CID 27161744.
Drewniok C, Wienrich BG, Schön M, et al. (2005). "Molecular interactions of B-CAM (basal-cell adhesion molecule) and laminin in epithelial skin cancer". Arch. Dermatol. Res. 296 (2): 59–66. doi:10.1007/s00403-004-0481-4. PMID 15278364. S2CID 20724995.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Cheng J, Kapranov P, Drenkow J, et al. (2005). "Transcriptional maps of 10 human chromosomes at 5-nucleotide resolution". Science. 308 (5725): 1149–54. Bibcode:2005Sci...308.1149C. doi:10.1126/science.1108625. PMID 15790807. S2CID 13047538.
Sivakumar S, Lieber S, Librizzi D, et al. (2023). "Basal cell adhesion molecule promotes metastasis-associated processes in ovarian cancer". Clin Transl Med. 13 (1): e1176. doi:10.1002/ctm2.1176. PMC 9842900. PMID 36647260.
Vainionpää N, Kikkawa Y, Lounatmaa K, et al. (2006). "Laminin-10 and Lutheran blood group glycoproteins in adhesion of human endothelial cells". Am. J. Physiol., Cell Physiol. 290 (3): C764–75. doi:10.1152/ajpcell.00285.2005. PMID 16236823.

External links

BCAM+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
Human BCAM genome location and BCAM gene details page in the UCSC Genome Browser.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This membrane protein–related article is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000187244 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000002980 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: BCAM basal cell adhesion molecule (Lutheran blood group)".

[pmid11133776-6] Parsons SF, Lee G, Spring FA, Willig TN, Peters LL, Gimm JA, Tanner MJ, Mohandas N, Anstee DJ, Chasis JA (2001). "Lutheran blood group glycoprotein and its newly characterized mouse homologue specifically bind alpha5 chain-containing human laminin with high affinity". Blood. 97 (1): 312–20. doi:10.1182/blood.v97.1.312. PMID 11133776. S2CID 10715366.

[pmid12244066-7] Kikkawa Y, Moulson CL, Virtanen I, Miner JH (2002). "Identification of the binding site for the Lutheran blood group glycoprotein on laminin alpha 5 through expression of chimeric laminin chains in vivo". J. Biol. Chem. 277 (47): 44864–9. doi:10.1074/jbc.M208731200. PMID 12244066.

[pmid36647260-8] Sivakumar S, Lieber S, Librizzi D (2023). "Basal cell adhesion molecule promotes metastasis-associated processes in ovarian cancer". Clin Transl Med. 13 (1): e1176. doi:10.1002/ctm2.1176. PMC 9842900. PMID 36647260.

v t e Proteins: clusters of differentiation (see also list of human clusters of differentiation)
1–50	CD1 a-c 1A 1B 1D 1E CD2 CD3 γ δ ε CD4 CD5 CD6 CD7 CD8 a CD9 CD10 CD11 a b c d CD13 CD14 CD15 CD16 A B CD18 CD19 CD20 CD21 CD22 CD23 CD24 CD25 CD26 CD27 CD28 CD29 CD30 CD31 CD32 A B CD33 CD34 CD35 CD36 CD37 CD38 CD39 CD40 CD41 CD42 a b c d CD43 CD44 CD45 CD46 CD47 CD48 CD49 a b c d e f CD50
51–100	CD51 CD52 CD53 CD54 CD55 CD56 CD57 CD58 CD59 CD61 CD62 E L P CD63 CD64 A B C CD66 a b c d e f CD68 CD69 CD70 CD71 CD72 CD73 CD74 CD78 CD79 a b CD80 CD81 CD82 CD83 CD84 CD85 a d e h j k CD86 CD87 CD88 CD89 CD90 CD91 - CD92 CD93 CD94 CD95 CD96 CD97 CD98 CD99 CD100
101–150	CD101 CD102 CD103 CD104 CD105 CD106 CD107 a b CD108 CD109 CD110 CD111 CD112 CD113 CD114 CD115 CD116 CD117 CD118 CD119 CD120 a b CD121 a b CD122 CD123 CD124 CD125 CD126 CD127 CD129 CD130 CD131 CD132 CD133 CD134 CD135 CD136 CD137 CD138 CD140b CD141 CD142 CD143 CD144 CD146 CD147 CD148 CD150
151–200	CD151 CD152 CD153 CD154 CD155 CD156 a b c CD157 CD158 (a d e i k) CD159 a c CD160 CD161 CD162 CD163 CD164 CD166 CD167 a b CD168 CD169 CD170 CD171 CD172 a b g CD174 CD177 CD178 CD179 a b CD180 CD181 CD182 CD183 CD184 CD185 CD186 CD191 CD192 CD193 CD194 CD195 CD196 CD197 CDw198 CDw199 CD200
201–250	CD201 CD202b CD204 CD205 CD206 CD207 CD208 CD209 CDw210 a b CD212 CD213a 1 2 CD217 CD218 (a b) CD220 CD221 CD222 CD223 CD224 CD225 CD226 CD227 CD228 CD229 CD230 CD233 CD234 CD235 a b CD236 CD238 CD239 CD240CE CD240D CD241 CD243 CD244 CD246 CD247 - CD248 CD249
251–300	CD252 CD253 CD254 CD256 CD257 CD258 CD261 CD262 CD263 CD264 CD265 CD266 CD267 CD268 CD269 CD271 CD272 CD273 CD274 CD275 CD276 CD278 CD279 CD280 CD281 CD282 CD283 CD284 CD286 CD288 CD289 CD290 CD292 CDw293 CD294 CD295 CD297 CD298 CD299
301–350	CD300A CD301 CD302 CD303 CD304 CD305 CD306 CD307 CD309 CD312 CD314 CD315 CD316 CD317 CD318 CD320 CD321 CD322 CD324 CD325 CD326 CD327 CD328 CD329 CD331 CD332 CD333 CD334 CD335 CD336 CD337 CD338 CD339 CD340 CD344 CD349 CD350

Basal cell adhesion molecule

Function

Interactions

References

Further reading

External links