ACTR1B

ACTR1B
Identifiers
Aliases	ACTR1B, ARP1B, CTRN2, PC3, ARP1 actin-related protein 1 homolog B, centractin beta, ARP1 actin related protein 1 homolog B, actin related protein 1B
External IDs	OMIM: 605144 MGI: 1917446 HomoloGene: 101541 GeneCards: ACTR1B
Gene location (Human)
Chr.	Chromosome 2 (human)
End	97,664,044 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	36,753,503 bp
RNA expression pattern
	Top expressed in
	prefrontal cortex; ; body of pancreas; ; Brodmann area 9; ; right uterine tube; ; right adrenal gland; ; body of stomach; ; right lobe of thyroid gland; ; ascending aorta; ; left uterine tube; ; right coronary artery;
	Top expressed in
	superior frontal gyrus; ; yolk sac; ; cerebellar cortex; ; lip; ; external carotid artery; ; neural tube; ; internal carotid artery; ; facial motor nucleus; ; proximal tubule; ; ankle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	nucleotide binding; protein binding; ATP binding; cytoskeletal protein-membrane anchor activity;
Cellular component	cytoplasm; microtubule cytoskeleton; cytosol; centrosome; extracellular exosome; cytoskeleton; membrane; dynactin complex; microtubule organizing center; extracellular region; secretory granule lumen; ficolin-1-rich granule lumen; cell cortex region;
Biological process	antigen processing and presentation of exogenous peptide antigen via MHC class II; neutrophil degranulation; establishment of mitotic spindle orientation; nuclear migration along microtubule;
	Sources:Amigo / QuickGO
Orthologs
	10120
	226977
	ENSG00000115073
	ENSMUSG00000037351
	P42025
	Q8R5C5
	NM_005735
	NM_146107
	NP_005726
	NP_666219
	Wikidata
View/Edit Human	View/Edit Mouse

Beta-centractin is a protein that in humans is encoded by the ACTR1B gene.^[5]^[6]^[7]

This gene encodes a 42.3 kD subunit of dynactin, a macromolecular complex consisting of 10 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. It is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit, like ACTR1A, is an actin-related protein. These two proteins are of equal length and share 90% amino acid identity. They are present in a constant ratio of approximately 1:15 in the dynactin complex.^[7]

References

^ a b c GRCh38: Ensembl release 89: ENSG00000115073 – Ensembl, May 2017
^ a b c GRCm38: Ensembl release 89: ENSMUSG00000037351 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Clark SW, Staub O, Clark IB, Holzbaur EL, Paschal BM, Vallee RB, Meyer DI (May 1995). "Beta-centractin: characterization and distribution of a new member of the centractin family of actin-related proteins". Mol Biol Cell. 5 (12): 1301–10. doi:10.1091/mbc.5.12.1301. PMC 301159. PMID 7696711.
^ Elsea SH, Clark IB, Juyal RC, Meyer DJ, Meyer DI, Patel PI (Jun 1999). "Assignment of beta-centractin (CTRN2) to human chromosome 2 bands q11.1→q11.2 with somatic cell hybrids and in situ hybridization". Cytogenet Cell Genet. 84 (1–2): 48–9. doi:10.1159/000015211. PMID 10343100. S2CID 83665096.
^ a b "Entrez Gene: ACTR1B ARP1 actin-related protein 1 homolog B, centractin beta (yeast)".

External links

ACTR1B human gene location in the UCSC Genome Browser.
ACTR1B human gene details in the UCSC Genome Browser.

This article on a gene on human chromosome 2 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000115073 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000037351 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7696711-5] Clark SW, Staub O, Clark IB, Holzbaur EL, Paschal BM, Vallee RB, Meyer DI (May 1995). "Beta-centractin: characterization and distribution of a new member of the centractin family of actin-related proteins". Mol Biol Cell. 5 (12): 1301–10. doi:10.1091/mbc.5.12.1301. PMC 301159. PMID 7696711.

[pmid10343100-6] Elsea SH, Clark IB, Juyal RC, Meyer DJ, Meyer DI, Patel PI (Jun 1999). "Assignment of beta-centractin (CTRN2) to human chromosome 2 bands q11.1→q11.2 with somatic cell hybrids and in situ hybridization". Cytogenet Cell Genet. 84 (1–2): 48–9. doi:10.1159/000015211. PMID 10343100. S2CID 83665096.

[entrez-7] "Entrez Gene: ACTR1B ARP1 actin-related protein 1 homolog B, centractin beta (yeast)".

ACTR1B

References

Further reading

External links